676 Botryomyeosis. 



but firmly adhere to tlie pulmonary tissue ; they are firm, tough, 

 tumor-like nodes, sections of which contain the soft foci above 

 described, or they may be homogenously fibrous, white or gray- 

 ish-white in color ; the milky fluid which may be expressed con- 

 tains fine granules. The surrounding pulmonary tissue usually 

 shows inflammatory changes. Lesions on the pleura or the peri- 

 cardium resemble tuberculosis of the serous membranes, with 

 the exception that the nodules are softer in their interior and 

 "sandy" (Piper). 



Similar tumors occur now and then in other internal organs, 

 usually in conjunction with involvement of the spermatic cord ; 

 thus in the kidneys, the suprarenal glands, the liver, the spleen, 

 the uterus, the maxillary sinuses, the udder, as well as certain 

 bones (maxillae and ribs), the spongy tissue of which is de- 

 stroyed by the tumor mass and the external lamella here and 

 there perforated. The regional lymph glands may be affected, 

 but as a rule they remain entirely free. 



In exceptional cases the morbid process is simultaneously 

 observed in a number of organs in a generalized form (Eieck, 

 Frohner, Kofler, Tiirnau). 



Symptoms. Botryomycom,ata usually develop very grad- 

 ually and without pronounced acute inflammatory symptoms. 

 They may occur on any portion of the skin as roundish or lob- 

 ulated, occasionally pedunculated fibroma-like tumors which now 

 and then attain a considerable size (collar boils and shoe boils 

 belong to this category) without affecting the movements of the 

 animal to any great extent, if at all (Fig. 112). In some cases, 

 however, the tumor becomes more diffuse, causing the formation 

 of extensive, very firm enlargements almost wood-like in con- 

 sistency, or of shield-like formations, from the surface of which 

 fistulous canals pass into the deeper tissues. Innumerable addi- 

 tional nodules may develop in rapid succession in the tissue of 

 the skin. These consist of lardaceous connective tissue with one 

 or more purulent, cheesy, mortar-like foci; the neighboring 

 lymph vessels remain intact, although the regional lymph glands 

 are occasionally enlarged, firm and bosselated and contain small 

 soft foci. The nodules may become transformed into crater- 

 shaped ulcers with prominent borders and discharge a tough, 

 muco-purulent, yellow secretion. 



Another frequent form of the disease is the (improperly) 

 so-called fistula of the spermatic cord which in most instances 

 is a result of infection with botryomyees (Johne). The process 

 develops very slowly and may extend over a period of 4 years 

 before the peritoneum is affected (Plosz) ; the tumor may attain 

 the size of a man's head and extend over the lower portion of 

 the abdomen. — In affection of the udder (quite common, accord- 

 ing to Sand) this organ becomes enlarged and firm nodes are 

 formed in its tissues. These nodes subsequently break and dis- 

 charge pus through fistulous canals. (In a case described by 

 Unterhossel the udder of a mare attained the size of that of 

 a cow.) In exceptional cases the disease appears also on the 



