Anatomical Changes. 693 



of dead bacilli, while Cantacu?ene and Eiegler observed enlargement of the spleen, 

 nephritis and swelling of Peyer's patches, and of the mesenteric and bronchial 

 lymph glands in guinea pigs, following intraatomachal administration of dead 

 bacilli of glanders. 



Anatomical Changes. In those cases where the skin and 

 subcutaneous connective tissue are affected, the skin may con- 

 tain nodes varying in size from a lentil to that of a pea, of firm 

 consistency and with soft centers, and round ulcers with ragged 

 edges that have developed from the latter, while on the other 

 hand (and more frequently) considerably larger abscesses and 

 nodes are present in the subcutaneous connective tissue. Sub- 

 sequently these may also ulcerate (see symptoms). The sur- 

 rounding tissue is gelatinously infiltrated or lardaceous and 

 glistening in appearance, firm in consistency and frequently 

 contains small foci composed of yellowish-gray or reddish 

 viscous pus. The lymph vessels between the nodes and ulcers 

 are enlarged and filled with a thick, yellowish-white coagulated 

 lymph; the regional lymph glands are much enlarged and firm 

 and their interior tough connective tissue is filled with small 

 pus foci. 



The respiratory organs are found affected almost without 

 exception in every case, sometimes the morbid process being 

 limited to the lungs while in other instances the upper air 

 passages and the nasal cavities are also involved. 



In the lungs the initial morbid changes are represented 

 either by small tubercle-like nodules or by large lobar pneu- 

 monic areas. The nodules consist of gray, hyaline or grayish- 

 white, firm structures ranging in size from a pin head to that 

 of a mustard seed imbedded in the lung tissue, occasionally 

 present in very large numbers and which are surrounded, in the 

 later stages of the process, by a hemorrhagic area (see p. 691). 



The catarrhal pneumonic form of pulmonary glanders 

 (broncho-pneumonia malleosa) appears in the form of small 

 atelectatic foci which are at first of an even brownish-red 

 color, but subsequently, as a result of central softening, become 

 transformed into a yellowish caseo-purulent mass and sur- 

 rounded by a firm, red, inflammatory halo which, like its im- 

 mediate surrounding area, has a peculiar yellowish gelatinous 

 sheen. 



In some of the more advanced cases large contiguous areas 

 of the lungs have become transformed into sarcoma-like, firm 

 though not very tough, structures (so called glanderous 

 growths). Upon section the surface is either uniformly grayish- 

 red or has imbedded in its structure numerous small purulent 

 or cheesy foci, in either case the peculiar gelatinous character 

 being evident. Glanderous foci of still greater age consist of 

 very tough, almost cicatricial connective tissue with cheesy or 

 mortar-like foci imbedded in its structure. 



More extensive or more acute affections of the lungs are 

 always attended with an acute bronchitis while the swollen 



