Symptoms, Diagnosis. 733 



of the body, which also become transformed into ulcers, while 

 the connecting lymph vessels form thick strands in the course 

 of which new nodules and ulcers develop. In this manner the 

 disease may continue for months, during which time it may 

 spread from the posterior to the anterior limbs, the trunk, the 

 neck, and even the facial portion of the head, and may finally 

 terminate in the death of the animal. In some cases the disease 

 may continue for years. In one case the nodes and ulcers 

 appeared only during the cold season while the affected horse 

 seemed perfectly healthy during the summer. 



The lymph glands in the region of the ulcerous processes 

 may occasionally undergo moderate swelling, but as a rule, 

 there is no induration, while suppuration never occurs. 



An unusual course of the disease is noted by Darmagnac inasmuch 

 as the ulcerous process spread in spite of proper treatment from the 

 inner surface of the thigh to the scrotum, and caused an extensive 

 swelling of the entire lower portion of the abdomen, fresh nodes 

 rapidly reappearing throughout its extent, some of them leading to the 

 formation of indolent fistulae. The constant loss of tissue secretions 

 finally caused the death of the horse, and post-mortem examination 

 revealed innumerable pus foci scattered throughout the firm lardaceous 

 connective tissue of the swelling. In addition to this there was also 

 simple hypertrophy of the inguinal and sublumbar lymph glands. 



Cocu observed in a mare of advanced age a large paranephritic 

 abscess, from the interior of which a fistulous canal communicated 

 with the outer world in the lumbar region. The right kidney, which 

 was surrounded by pus, contained in its otherwise normal parenchyma 

 numerous abscesses ranging in size up to that of a pigeon's egg. Nocard 

 demonstrated the above named bacillus in the pus. — The authors ob- 

 served a similar paranephritic abscess as large as a man's head at 

 the post-mortem examination of an ass, they could also demonstrate the 

 bacillus referred to in a purulent secretion of an otherwise benign 

 wound of the fetlock of a horse which healed perfectly. 



Diagnosis. The disease resembles cutaneous glanders in 

 many respects. The differences are that the small ulcers which 

 develop from the nodes in ulcerous lymphangioitis heal rapidly, 

 the lymph glands are hardly involved in the process, the nasal 

 mucous membrane remains intact and the mallein test gives no 

 positive reaction. In the pus of the nodes and in the secretion 

 of the ulcers short Gram positive bacilli can be demonstrated, 

 which do not thrive on naturally acid potatoes. Finally, intra- 

 peritoneal infection of guinea pigs is followed more rapidly by 

 periorchitis than is the case in infection with glanderous 

 material, the bacilli in question are found in great masses in 

 the purulent fibrinous exudate, while pus foci are found in the 

 parenchymatous organs. 



Epizootic lymphangioitis is in general a more malignant 

 disease while the lymph glands also usually suppurate and the 

 pus contains large globular schyzomycetes which do not stain 

 readily. — Contagious acne is probably closely related etiologic- 



