Treatment. - 739 



&_Teppaz had favorable results in the treatment of mild cases 

 with atoxyl, although this gave no results in severe forms of 

 the disease. 



Prophylaxis consists in the isolation of the diseased ani- 

 mals, destruction of morbid products and disinfection of stables 

 with strong disinfectants. 



Literature. Eivolta & Micellone, Giorn, die Anat., Fis. et Patol., 1883. 

 143 — Nocard, Bull., 1897. 367. — Tokishige, Cb. f. Bakt., 1896. XIX. 105. — 

 Baruchello, Sul. fare, criptoe., Torino 1898. — MacFadyean, J. of eomp. Path., 

 1903. XVI. 379. — Martin, J. of comp. Path., 1905. XVIII. 81. — Sullivan, Vet. 

 Eec., 1905. Nr. 870. — Sanfelice, Z. f. Hyg., 1906. LIV. 299. — Mrowka, Z. f. Vk., 

 1906. XVIII. 261 — Marcone, Eev g6n., 1907. IX. 249. — Pricolo, ibid., 1907. X. 

 457. — Ducloux, Soc. biol., 1908. LXIV. 593. — Thiroux & Teppaz, A. P., 1909. 

 XXIII. 420. 



Malignant Hyphomycosis of Horses. Leeches (Hyphomykosis 

 destruens equi.) In India as well as on the Sunda Islands a 'disease 

 occurs among horses whieli is known by the name "bursattee" 

 (burus^rain), and which has been described in particular by F. Smith 

 and Stell, and more recently also by deHaan and Hoogkamer. Ac- 

 cording to Lyford and Bitting this same disease occurs quite frequently 

 in North America among horses and mules where it is known as 

 "leeches" while in Europe only a single case has been observed by 

 Drouin & Renon in Alfort. 



The morbid symptoms consist in the appearance of very firm 

 nodules under the skin of the lips, the nasal alae, the eyelids, the neck, 

 the body and the limbs, finally also in the mucous membrane of the 

 gums and the nasal cavities; these gradually enlarge and later become 

 transformed into ulcers. The ulcers have uneven, ragged, easily bleed- 

 ing granulating borders which communicate with deep, sinuous, fistulous 

 canals which occasionally extend to or into the bones (perforation of 

 the hard palate has also been observed). Within the ulcers and 

 fistulous canals as well as in the interior of the nodes are found grayish- 

 yellow, occasionally also calcified masses and cores which may approach 

 the size of an egg and have a bosselated surface, these are firmly 

 attached to the surrounding tissue by means of their ramifications. The 

 lips, nasal alae and eyelids may be extensively swollen, while the mouth 

 and nose discharge a bloody mucous mass. The affected regions of 

 the body seem to cause excessive itching. In severe cases, which how- 

 ever do not involve the regional lymph glands, the nutrition of the 

 patients suffers seriously. 



The grayish-yellow cores above mentioned contain branching 

 mycelia and free spores of a mold fungus imbedded in hyaline con- 

 nective tissue bundles and leucocytes; according to deHaan these form 

 a delicate sod on nutrient agar while in acid bouillon they form groups 

 of delicate balls. Experimental inoculations have failed to give positive 

 results. 



The treatment consists in an early extirpation or cauterization of 

 the affected portions of the cutis ; deDoes observed healing of the lesions 

 in the mucous membranes after internal iodine treatment (10-30 gm. 

 potassium iodide daily) while deHaan & Hoogkamer found this treat- 

 ment ineffective. 



Literature. Drouin & Eenon, Soc. biol., 1896. 425. — De Haan & Hoog- 

 kamer, A. f. Tk., 1903. XXIX. 395. 



