872 Leukemia, of Mammals. 



The kidneys are also considerably enlarged on account ol a 

 diffuse infiltration with white blood corpuscles and on account 

 of the presence of larger or smaller lymphomas. In the intes- 

 tinal wall, especially in the posterior part of the small intestines, 

 various sized lymphomas are found, which protrude into the 

 lumen of the intestines, and may contract the same considerably. 

 In one of Olt's cases a chylusthrombosis developed in a dog. 

 On the serous membranes and in the lungs nodules consisting 

 of lymphadenoid tissue may sometimes be found and the inter- 

 lobular connective tissue of the lungs may contain extensive 

 areas of infiltration. In the heart, the peri- and endocardium 

 of which may be permeated by white areas of infiltration or 

 small lymph nodules, a great quantity of very soft blood 

 coagulum may be present. The blood shows changes as de- 

 scribed below. Similar cellular infiltrations may frequently be 

 found also in other organs, thus on the cerebral meninges, in 

 the uterine walls, in the various glands, as well as in the con- 

 nective tissue of any other of the organs. Hemorrhages are 

 not infrequently present in some of the organs. 



Symptoms. Leukemia always develops insidiously. Eapid 

 tiring is observed, especially during work, the animal perspires 

 easily and shows in general the symptoms of pulmonary 

 emphysema. Soon indications of languor and depression ap- 

 pear also during rest, the appetite becomes capricious and later 

 entirely depressed, while thirst is not infrequently increased. 

 The pale discoloration of the mucous membrane becomes more 

 and more conspicuous, so that the mucous membranes finally 

 take on a porcelain white color. The heart's action is accelerated 

 and throbbing, the heart sounds being sometimes obliterated by 

 secondary sounds, the pulse accelerated and small. Gradually 

 emaciation becomes perceptible ; edematous swellings appear on 

 different parts of the body. The hair becomes lusterless and 

 scanty. 



In most cases a chronic swelling of the lymph glands ap- 

 pears symmetrically on both sides of the body. Enlargements 

 which vary in size, dense, roundish, not painful, are found in 

 the submaxillary space and in the vicinity of the pharynx, on 

 the neck, along the jugular groove, on the chest, in the axillary 

 Region, and in both inguinal regions, as well as in all places 

 where lymph glands occur. The skin covering them is normal 

 and easily raised. Because of the enormous enlargement of 

 'the lymph glands locomotion is interfered with, either from 

 purely mechanical causes or by compression of the neighboring 

 nerve trunks. In infection of the internal lymph glands func- 

 tional disturbances of some of the organs may result. Thus 

 the compression of the bronchi or of the vagus nerve may 

 cause difficulty in respiration, roaring, and even attacks of 

 asphyxiation. At first this may appear only during work, later 

 however also during rest. The compression of larger blood 



