Anatomical Changes. 



941 



become more slender and finally roprescnt a veritable lattice work of splinters. 

 Finally multinucleated giant cells are deposited around the laminae and cause their 

 disappearance by lacunar absorption (Hintzo). 



In addition to tlie changes in the bones, symptoms of 

 anemia, gastro-intestinal catarrh, or catarrhal affections of the 

 respiratory organs are often observed; in the latter organs 

 broncho-pnenmonia is frequent. 



'■"T.-i^b 





Fig. 159. Rachitis. Longitudinal section through the line of ossification of the upper 

 diaphyseal end of the femur, a. unchanged hyaline cartilage ; 6. cartilage in the 

 first stages of proliferation ; c. zone of proliferated cartilage columns; d. columns of 

 proliferated hypertrophic cells; e. vascular marrow spaces: f calcified cartilage tis- 

 sue ; (/. osteoid tissue ; h. remnants of cartilage tissue between osteoid tissue ; i. tra- 

 bcculae of osteoid tissue; k. trabeculae of osteoid and developed (lime containing) 

 bone tissue; I. vascular, cellular-fibrous marrow spaces. (Magnif. 50 X. After 

 Ziegler.) 



Symptoms. The development of the rachitic manifesta- 

 tions proper is sometimes preceded by disturbances in nutri- 

 tion. The animals seem weak, their desire to eat is diminished, 

 the belly somewhat bloated, and at the same time obstinate 

 diarrhea makes its appearance. Sometimes there may be 

 symptoms of pica (licking disease), gnawing the walls or the 

 wood of the stable, drinking of manure water; these occur not 

 only in the initial stage, but also in the further course of the 

 disease. In some cases, especially in colts, the second dentition 



