LOCOWEED DISEASE OF SHEEP 417 



lymphoid cells. The desquamated endothelial cells dominated the appearance in the 

 sinuses. The blood vessels of the Ismiph gland were markedly congested. 



Voluntary muscle. Poorly preserved, showed small bodies which were not very 

 distinct but appeared to be sarcosporidia. 



Section through abscess cyst of omentum. Cyst was about 1 cm. x i. Capsule 

 thin, the outer part being made of laminated connective tissue, the inner portion 

 of young granulation tissue in which there were great numbers of cells resembling 

 large mononuclear leukocytes, and a number of small mononuclears, together with 

 many rather granular and swollen cells of fibroblastic appearance. The inner edge of 

 the wall passed off suddenly into a region of coagulation necrosis in which were found 

 fragmenting nuclei, polymorphonuclear leukocytes and purple debris. This was 

 continuous with a pinkish granular debris filling the center of the cavity. There was 

 no evidence of daughter tubercle formation in the wall of the cyst but the general 

 appearance suggested tuberculosis as a possible diagnosis. 



Autopsy 17. Lamb 58, from Corral VII (no alfalfa), had become very ill but had im- 

 proved markedly when fed on alfalfa, when the experiment was interrupted, and had 

 remained fairly well after being returned to the loco diet; was removed from the corral 

 for the examination. The temperature of the lamb was 101 (rectal temperature); the 

 lamb was emaciated and stiff-legged but was not one of the illest lambs in the corral. 

 It coughed a good deal but seemed in better condition than it had been previous to 

 the diet of alfalfa hay. IJs weight was twenty-three pounds. The animal was chloro- 

 formed and autopsied at once on August 19. 



Anatomical diagnosis. Oestrus avis infection of nasal passages with muco-puru- 

 lent inflammation. Multiple pin head bronchopneumonic patches in both lungs. 

 Emaciation. Infarction in liver; Thysanosoma actinioides hepatitis. Irregular in- 

 cisor teeth. 



The skin, muscles, and peritoneal cavity were clear; there was a small amount of 

 fat. The spleen was. small, soft, translucent, the structures appearing normal. The 

 liver was smooth, semi-translucent excepting for an irregular wedge-shaped area on 

 the upper surface on the left lobe just to the left of njidline. This area was not raised, 

 was smooth' and had a mottled, grayish red color with fine, pin point dark mottlings. 

 On section the area was wedge-shaped extending IJ cm. into the liver. The kidneys, 

 pancreas, and bile ducts, stomachs, pelvic viscera, and adrenals presented no ab- 

 normality. One small, fringed tapeworm found in the intestines. Heart contained 

 a fair amount of fat; was clear throughout except that muscle was rather gray and 

 opaque. 



The lungs were voluminous, surface smooth, for the most part pink, but mottled 

 at irregular intervals with dark red points varying from a pin head to 1 cm. in size. 

 On section the dotted appearance was also seen as if from very numerous, small 

 areas of consolidation. There were no tubercles and no cavities found. The right 

 and left lung were alike. The bronchi and trachea contained frothy, blood-tinged 

 mucus. The turbinated passages were swollen, dark red and covered with muco-pus. 

 A large Oestrus larvae and six small ones were found in the nasal passages. The in- 

 cisor teeth were unusually long. 



Microscopic report. Heart striations and fibrillations distinct, often the clear 

 space around the heart nucleus seemed rather larger than usual. No other noticeable 

 alteration. Lung, showed small regions in which the alveoli were packed with red 

 cells and coagulated albumin, alternating with relatively normal lung. In the region 



