418 UNIVERSITY OF VIRGINIA PUBLICATIONS 



with exudate there were remarkably few leukocytes and only a few desquamated 

 epithelial cells. No fibrin was made out in the H. and E. specimen. The bronchi were 

 practically clear. The alveolar capillaries in general congested. Spleen, malpighian 

 bodies conspicuous, rather dense, and larger than usual, apparently however, a nor- 

 mal spleen. 



Liver. A small block showed considerable thickening throughout the portal 

 systems, chiefly around the bile ducts with rather edematous tissue. The central 

 third of the section was devoid of liver tissue and showed a mass of cellular material 

 with two or three areas of necrosis. In this tissue were dilated bile ducts. The cel- 

 lular tissue was composed of fibroblasts of various size, many of which contained a 

 slight amount of brownish pigment. Among them were mononuclears, polymorpho- 

 nuclears and eosinophiles. The eosinophiles were abundant and in part appeared 

 to have poljonorphous nuclei, in other less frequent instances, single, round nuclei. 

 Compressed and degenerating liver tissue was found at the edge of this cellular ac- 

 cumulation and evidence of the extension into the liver of the newly forming connec- 

 tive tissue was met with. At the edge of the connective tissue there was hemorrhage 

 into the liver. Elsewhere the liver'cells were cloudy, vacuolated and granular. 



Kidney showed a moderate amount of coagulated albumin in the tubules. The 

 convoluted tubular epithelium moderately cloudy, otherwise the kidney appeared 

 normal. Mucosa of nares; the most striking feature was the very great dilatation 

 of the blood sinuses and bood vessels^ the intervening tissue being distinctly edema- 

 tous. In the edematous tissue were found numerous eosinophiles with polymorphous 

 nuclei, large mononuclears and a few lymphocytes. The eosinophile was the most 

 striking and probably the most abundant infiltrating cell. The epithelium of the 

 glands was very cloudy and full of mucus. Immediately beneath the surface epithe- 

 lium there were rather dense accumulations of mononuclears, chiefly lymphocytes, 

 the eosinophiles being less abundant in this region. Section of lymph gland, showed 

 widely dilated central sinuses with phagocytic endothelial cells. Voluntary muscle 

 appeared clear, no sarcocysts being found. Epithelium and wall of esophagus ap- 

 peared normal. 



Autopsy 18. Lamb 47 from Corral VIII. The lamb had been very feeble but had 

 improved during the week of alfalfa feedings. Subsequently it fell into worse con- 

 dition and died on the evening of August 21. The autopsy was performed at 2 p.m., 

 August 22. 



Anatomical diagnosis. Oestrus ovis infection; acute mucopurulent inflammation 

 of mucous membrane lining the nasal passages and accessory sinuses; bronchopneu- 

 monia with abscess formation. Infection with Thysanosoma actinioides. Irregular 

 incisor teeth. 



The animal weighed 15 pounds, its wool was ragged, incisor teeth loose and long. 

 Emaciation was extreme. The peritoneal cavity was clear, there was no fat visible, 

 the mesenteric glands were large, pale and soft. 



The liver, spleen and kidneys appeared normal. A small fringed tapeworm was 

 found in the small intestine. The stomachs appeared normal. Both lungs were ad- 

 herent over the ventral and.cephalad portions by fibrous adhesions, denser on the 

 right side. In each lung were multiple small areas of consolidation with abscess 

 formation. The bronchi contained bloody mucus. Heart appeared normal, except 

 for absence of fat. On opening the head the engorgement of the mucous membrane of 

 the nasal passages was intense, there being many larvae crawling over the mucous 

 membrane with muco-pus and pin point hemorrhages into the mucosa. 



