394 UNIVERSITY OF VIRGINIA PUBLICATIONS 



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August 27, 1904, one of Forsyth's sheep was shot and at the same time bled from 

 the carotid. 



Autopsy 2S. Postmortem at once. The sheep was thin but not emaciated, there 

 was a heavy infection with Thysanosoma actinioides in the common and hepatic 

 ducts; over fifty-six small wire worms were found in the fourth stomach. Tl;e incisor 

 teeth were long. There was a small amount of black sand in the pelvis of the left 

 kidney. Hemorrhagic spots were found in the lungs and there was a hair ball in the 

 fourth stomach measuring about 4 x 2 x 1.5 cm. On microscopic examination small 

 sarcocysts were found in the myocardiiun; and pin point areas of extravasation into 

 the alveoli of the lung. The liver cells were distinctly vacuolated, the capillaries 

 being indistinct and compressed. Even the small bile ducts were altered, but the 

 change was more marked in the larger ducts. These were distended, frequently 

 filled with exudate and surrounded by cellular and fibroblastic tissue. The fibro- 

 blast formation was only moderate and had invaded the liver tissue to only a slight 

 extent. The cells surrounding the bile ducts were polymorphonuclears, large and 

 small lymphoid cells and fibroblasts. An increased number of polymorphonuclears 

 were present in the portal veins. Occasionally a small duct was found packed tightly 

 with leukocytes so that the wall could hardly be recognized. The spleen showed 

 qytolysis of red blood cells; the kidneys and adrenals were apparently normal. In 

 a section through a lymph gland the sinuses were found dilated, as previously de- 

 scribed, and containing eosinophils, phagocytic endothelial cells and many granules 

 of brownish pigment, like blood pigment. The voluntary muscle contained a few 

 sarcocysts. Section of the fourth stomach showed no definite evidence of lesion from 

 the wire worms; there was no reaction of an inflammatory character in the mu- 

 cosa or sub-mucosa. Esophagus. Both epithelium and muscle wall appeared to be 

 normal. 



Autopsy 24. A two year old ewe from the Forsyth ranch was shot and at the same 

 time bled from the carotid and autopsied at once on August 27. The animal was 

 in fair flesh, the chief findings being that the common bile ducts and hepatic ducts 

 were packed with Thysanosoma actinioides which also extendied far back into the 

 smaller liver ducts. The bile ducts were thickened and dilated and there were pin 

 point hemorrhages into the mucosa. There was beginning necrosis of a wedge-shaped 

 area on the cephalad surface of the right lobe of the liver. Twenty, or more, wire 

 worms were found in the fourth stomach and Oestrus larvae in the supraorbital 

 sinuses. There were small points of hemorrhage in the lungs. On microscopic ex- 

 amination the heart showed a moderate infection with sarcocysts, one of which 

 was found in a large Purkinje cell. The lung and spleen appeared normal. The 

 liver showed very marked changes especially in the region of the capsule of Glis- 

 son. At one place a widely dilated bile duct was cut across showing in the lumen 

 a section through a tape-worm. The structure of the duct wall was practically lost 

 and around the duct there was marked inflammation with necrosis of liver tissue, 

 abscess formation and the evidences of chronic inflammation. "Small regions 

 of necrosis were scattered for quite a distance out from the main bile duct and the 

 bile ducts all over the section showed thickening and infiltration around them. The 

 outer zones of lobules were much more affected than the inner two-thirds except near 

 the affected duct described above where lobules were destroyed. Kidney, cloudy. 

 Cross section of lymph gland showed dilated sinuses and hyperplasia, as in previous 

 case. 



