AEEEST OP HEMORllHAGE 9 



The wMte thrombus is formed by the white blood cells and 

 Bizzozero's blood plaques, and is, so to speak, a physiological 

 product and not a coagulum. The red thrombus is a patho- 

 logical product, consisting of a fibrin constituted coagulum 

 ■plus red blood cells naet with in the vessels of animals 

 suffering with septic disease. 



What becomes of the white thrombus ? 



When aseptic, it organizes ; when infected, it softens and 

 breaks up into emboli. 



What is understood by organisation of a thrombus ? 



Its replacement by connective tissue. The new con- 

 nective tissue formed results from proliferation of the endo- 

 thelial cells of the vessel ; the thrombus itself only plays, 

 a passive role. The endothelial cells of the intima of the 

 vessel take on a spindle shaped and multiform character, 

 advance, perforate and surround the thrombus, developing 

 later into fibrillar connective tissue cells, thus replacing the 

 thrombus by connective tissue ; while this occurs new blood 

 vessels are formed from the vasa vasorum. This is termed 

 the vascularization of the thrombus. 



Sow much time is consumed in the process of organization, 

 and vascularization ? 

 About four weeks. 



What else may become of a thrombus 9 



It may calcify and form a phlebolit (vein stone). 



How is the circulation interrupted by the thrombus re- 

 established ? 

 A collateral circulation forms. The vasa vasorum be- 

 come larger and the central and peripheral arterial branches, 

 of the thrombus meet. 



