12 CALIFORNIA ACADEMY OF SCIENCES. [3D Ser., 



As regards the granulation of the cytoplasm, we can nearly 

 always, in successful preparations, distinguish three distinct 

 kinds besides that of the granosphere. The achromatic 

 granule is strongly refractive and pure white, generally 

 but not always globular, or aggregated into larger globules, 

 around which the two other granulations are sparsely scattered 

 as irregularly formed grains of various sizes. Some of 

 them stain deep blue, while others have a reddish tint, 

 fainter and more bluish than the grains of the granosphere. 

 It appears as if the achromatic granula were of a much 

 greater consistency than the two chromatic ones, as they 

 assume the shape of regularly rounded granules, while the 

 colored grains surrounding them appear compressed or 

 stretched out, accommodating themselves to the greater 

 consistency of the achromatic granule. This refers to the 

 toluidine stain preparations. 



Smaller Mononucleary Lericocytes. — These occur in vary- 

 ing numbers, according to the state of the blood. The nu- 

 cleus is very large, round, and compact, while the cytoplasmic 

 part is very small, being reduced to a narrow margin. 

 Frequently this cytoplasmic part stains as if it contained 

 haemoglobin, and this makes me doubtful as to whether 

 these bodies are really leucocytes. Fig. 20 represents one 

 of them. The cytoplasm generally stains much lighter than 

 is figured, but now and then we find a corpuscle intensely 

 stained, as is this one. 



Leucocytes with Eosino-phile Granulation. — These are al- 

 ways scarce and vary greatly in size. They show cytoplasm 

 frequently rayed as that of the true leucocytes, but the stain- 

 ing of the parts is reversed. The granulation stains deeply, 

 while the rays, probably corresponding to the grano- 

 sphere, remain pale as in fig. 13. The centrosomes stand 

 out plainly, but the inner spheres do not differentiate. Figs. 

 19 and 20 represent two of these cells of different sizes. 

 There are some that are yet larger, and these stain less. 

 The smaller the cell the darker it stains. 



Leucocytesof Various Kinds in Dissolution . — The cytoplasm 

 and the nucleus appear to disintegrate together. In many 



