Passage of Crystalloids into and out of the Tissues. 61 



After a quarter of a grain of chloride of lithium, in five hours 

 and a quarter the aqueous humour showed lithium, and all the 

 organs showed lithium, but none was in the lens. In another pig, 

 in twenty-four hours all the organs showed less lithium, and none 

 was found in the aqueous humour. 



After a quarter of a grain, in five hours and thirty-five minutes 

 lithium was distinct in the aqueous humour, and very faintly traceable 

 in the lens ; and after sixteen days the minutest traces of lithium 

 could be detected in the lens, the liver, the kidney ; but no trace 

 could be found in the blood. 



After three grains of chloride of lithium, in four hours lithium was 

 in the hair of the belly, and for thirty-two days the urine showed 

 lithium very distinctly. The thirty-third day after the lithium the 

 lens was found to contain minute traces of lithium, and even after 

 thirty-nine days the lithium was in the alcoholic extract of the urine. 



With three grains of chloride of lithium, a young pig in half an 

 hour had lithium in the watery extract of the lens. In the same time 

 an old pig had no lithium in the lens. 



With two grains, a young pig in six hours had lithium distinctly 

 throughout the whole lens. An old pig in the same time had lithium 

 in the outer part of the lens, but scarcely the minutest trace in the 

 inner part of the lens. 



4. Experiments on Healthy Persons and on Cases of Cataract. 



Ten grains of carbonate of lithia, taken three or four hours after 

 food by a man, require from five to ten minutes to pass from the 

 stomach to the urine, and this quantity of lithia will continue to pro- 

 duce traces of lithium in the urine for from six to seven days. 



Two grains of chloride or carbonate of lithia, taken shortly after 

 food by a boy, gives no appearance in the urine until from ten to 

 twenty minutes ; and this quantity continues to pass out for five, 

 seven, or eight days. 



Experiments made by the ordinary mode of analysis showed that 

 four grains of sulphate of protoxide of iron, taken by a man almost 

 fasting, gave a trace in the urine in seven minutes. Seven grains 

 gave distinct appearance in ten minutes ; and in ten minutes and a half 

 one grain of iodide of potassium, taken by the same man fasting, 

 appeared in the urine in twelve minutes. 



When no lithia had been taken, seven cataracts were examined 

 most carefully, and only one showed an exceedingly feeble trace of 

 lithium. 



When twenty grains of carbonate of lithia were taken twenty-five 

 minutes before the operation, the lens showed no lithium. 



When twenty grains of carbonate of lithia were taken two 

 hours and a half before the operation, the lens showed lithium in 

 the watery cataract. 



When twenty grains of carbonate of lithia were taken between 

 four and five hours before the operation, the lens showed lithium 

 in each particle. 



When twenty grains of carbonate of lithia were taken seven hours 

 before the operation, the lens showed lithium in each particle. 



