= a 
ta 
on 
. 
714 Prof. I. Traube: Contribution to the Theories 
examine whether the same law holds good for the narcotic 
action of those substances. 
By the cerebral narcosis of tadpoles Overton* has deter- 
mined that the equivalent quantities of dissolved alcohols 
given in the table under the headings have exactly the same 
narcotic effect. Under 2 are to be found the relative equivalent 
quantities of the same alcohols that—according to Joffroy 
and Serveaux’s experiments [—prove fatal to rabbits on intra- 
venous injection. 
Very fine are those experiments carried out in several 
parallel series on the development of fertilized eggs of the 
sea-urchin by Dr. H. Fiihner{ in the biological stations 
of Heligoland and Villefranche ; by quantitative methods, 
| { 
Jorrroy & SERVEAUX.|| OVERTON. Finer. | 
| 
On Rabbits. | On Tadpoles, On Sea-Urchin Eggs. 
Z aa | 
Quo- Molee. Quo- Quo- 
tients. || per litre. | tients. _ tients, | 
Methyl aleshot ..| | 02er a 
Ethyl aleohol ...| 0°408 St ogg | 2001 game a 
! n-Propyl alcohol | 0°090 Od) Atle 0-136 3:0 | 
#-Butyl alcohol...| — ...... | 929: 0-088... 0:045 | 
Isopropyl alcohol) ...... 013 | SO cll eee | 
Isobutyl aleohol.| 0-031 3-1 | 0-045 4) |i eaneas | 
Isoamyl alcohol. | 0-010 a 0-020 . 
n-Heptyl alcohol |__...... Pre Se Ps hace 000170 33 . 
n-Oktyl aleohol...| — ...:.-. | tot weakens Cor: 0:00051 | 
Oapryl alcohol...) ...... | | 0:0004 | 0:0008 
f : + ie Re a GR a. 
| iF EE, 0 
| ) OvERTON. 
| | On Tadpoles. | 
| “Molec. per litre.|  Quotients. | 
SD A A et Ae ak See | 
Mirehone ht ak ae eee tes | 0:26 ¢ 
Methyl ethyl ketone............... | 0-09 | a0 
Diethiy! hetone sox. 5. 10). wea 0-029 ae 
Methyl acetate oo tc ccsscseceon an | 0:08 9. 
igh yivacbiaties >: £5. ieee / 0:03 Als 
Propylsacebabe: bac ccs oa acre | 0:0105 =e 
Tsobmbyl acetate: (32-0465. -¢-eceaes 0-057 | ; 
Isbamyl aceliabe.. Accs. 0. esonee / 0-019 | se | 
* Overton, Studien iiber die Narkose, Jena, 1901. 
+ Jotfroy and Serveaux, Arch. de médec. expér. et d’ Anatom. pathol. 
vil. p. 569 (1895). 
{ H. Fuhner, Arch. fiir exper. Pathol. u. Pharmakol. li. p. 1, 1908, and 
li. p. 69, 1904. 
