1102 MANUAL OF DETERMINATIVE BACTERIOLOGY 



against infection with organisms ob- mals, except rarely in an atypical form 



tained from verruga cases. in monkeys. Experimental verruga per- 



Serology : Immune sera fix complement uana has been produced in man, in a 



and agglutination of suspensions of number of species of monkeys and occa- 



Bartonella by sera from recovered cases sionally in dogs, 

 has been reported. Source : Blood and endothelial cells 



Pathogenicity : Three forms of the dis- of lymph glands, spleen and liver of 



ease occur in man; the anemic (Oroya human cases of Oroya fever, 

 fever), the eruptive (verruga peruana) Habitat: Blood and endothelial cells 



and mixed types of both of the other of infected man, probably also in sand 



forms. Experimental Oroya fever has flies (Phleboiomus verrucarum and Phle- 



not been successfully produced in ani- botomus noguchii). 



Genus II. Haemobartonella Tyzzer and Weinman. 

 (Amer. Jour. Hyg., 30(B), 1939, 141.) From Greek haemos, blood and the generic 



name Bartonella. 



Includes parasites of the red blood cells in which there is no demonstrable multi- 

 plication in the tissues and which do not produce cutaneous eruptions. They are 

 typically rod- or coccoid-shaped, showing no differentiation into nucleus and cyto- 

 plasm, occurring naturally as parasites of vertebrates, and are transmitted by arthro- 

 pods. They are distributed over the surface of the erythrocj'tes, and possibly some- 

 times within them. They stain well with Romanowsky type stains and poorly 

 with other aniline dyes. Gram-negative. Not cultivated indefinitely in cell-free 

 material. Rarely produce disease in animals without splenectomy, are markedly 

 influenced by arseno therapy, and are almost all of world-wide distribution. The 

 experimental host range is restricted, infectivity of a rodent species for other rodents 

 being common, but for primates unknown. 



The type species is Haemobartonella muris (Mayer) Tyzzer and Weinman. 



Key to the species of genus Haemobartonella. 

 I. The etiological agent of haemobartonellosis of the white rat. 



1. Haemobartonella muris. 

 II. The etiological agent of haemobartonellosis of the dog. 



2. Haemobartonella canis. 



III. The etiological agent of haemobartonellosis of the vole. 



3. Haemobartonella microtii. 



IV. The etiological agent of haemobartonellosis of the guinea pig. 



4. Haemobartonella tyzzeri. 

 V. The etiological agent of haemobartonellosis of cattle. 



5. Haemobartonella bovis. 

 VI. The etiological agent of haemobartonellosis of the buffalo. 



6. Haemobartonella sturmanii. 

 VII. The etiological agent of haemobartonellosis of the deer mouse. 



7. Haemobartonella peromyscii. 

 VIII. The etiological agent of haemobartonellosis of the gray-backed deer mouse. 



7a. Haemobartonella peromyscii var. 

 maniculati. 

 IX. The etiological agent of haemobartonellosis of the short-tailed shrew. 



8. Haemobartonella blarinae. 

 X. The etiological agent of haemobartonellosis of the gray squirrel. 



9. Haemobartonella sciurii. 



