FAMILY BORRELIOTACEAE 



1237 



O. Bang, Acta path, et inicrobiol. Scand., 

 Suppl., 11, 1932, 180-182; Carini and Ma- 

 ciel, Bull. Soc. Path, exot., 5, 1912, 576- 

 578; F0lger, Acta path, et microbiol. 

 Scand., Suppl., 11, 1932, 182-187; Glover, 

 Brit. Jour. Exp. Path., 20, 1939, 150-158; 

 Gowen and Schott, Am. Jour. Hj^g., 18, 



1933, 674-687; Hurst, Jour. Exp. Med., 

 58, 1933, 415-433; 69, 1934, 729-749; 63, 

 1936, 449-463; Koves and Hirt, Arch, 

 wissensch. u. prakt. Tierheilk., 68, 1934, 

 1-23; Morrill and Graham, Am. Jour. Vet. 

 Res., 2, 1941, 35-40; Brit. Jour. E.xp. 

 Path., 15, 1934, 372-380; Shope, Proc. 

 Soc. Exp. Biol, and Med., 30, 1932, 308- 

 309; Jour. Exp. Med., 5J!^, 1931, 233-248; 

 57, 1933, 925-931 ; 62, 1935, 85-99, 101-117, 

 Traub, ihid., 58, 1933, 663-681; 61, 1935, 

 833-838. 



3. Scelus beta spec. nov. From beta, 

 second letter of Greek alphabet, in ref- 

 erence to common name. 



Common name : B virus. 



Hosts : HOMINIDAE — Homo sapiens 

 L., man. CERCOPITHECIDAE—Ma- 

 caca mulatta (Zimmermann), rhesus 

 monkey. E.xperimentally, also LEPOR- 

 IDAE — Oryciolagus cuniculus (L.), rab- 

 bit. CAVIIDAE—Cavia-porcellus (L.), 

 guinea pig. 



Geographical distribution: United 

 States (from captive monkeys and man). 



Induced disease : In man, local and rela- 

 tively insignificant lesion on bitten part, 

 later flaccid paralysis of legs, urinary 

 retention, ascending paralysis, and death 

 by respiratory failure. In Macaca viu- 

 latta, experimentally by intracutaneous 

 injection, hemorrhagic or vesiculo-pustu- 

 lar lesions without later involvement of 

 central nervous system but with subse- 

 quent acquired immunity. Acidophilic 

 intranuclear inclusions in lesions. 



Transmission : To man, by bite of mon- 

 key. To monkey, experimentallj', by 

 injection. 



Literature : Burnet et al., Austral. Jour. 

 Exp. Biol, and Med. Sci., 17, 1939, 35-40, 

 41-51; Sabin, Brit. Jour. Exp. Path., 15, 



1934, 248-268, 268-279, 321-334 ; Sabin and 



Hurst, ibid., 16, 1935, 133-148; Sabin and 

 Wright, Jour. Exp. Med., 59, 1934, 115- 

 136. 



4. Scelus tertium spec. nov. From 

 Latin tertius, third. 



Common name: Virus III of rabbits. 



Host : LEPORIDAE-^Oryctolagvs cu- 

 niculus (L.), domestic rabbit. 



Insusceptible species : No obvious dis- 

 ease in inoculated guinea pig, white 

 mouse, monkej^ {Macaca mulatta Zim- 

 mermann), rat, or man; hence the as- 

 sumption that these are naturally im- 

 mune, but they may be merely tolerant or 

 klendusic. 



Geographical distribution : L'nited 

 States (apparently spontaneous in some 

 individuals of the laboratory rabbit). 



Induced disease : In domestic rabbit, 

 experimentally, after incubation period 

 of 4 to 6 days, failure to eat, loss of weight , 

 occasionallj^ diarrhea and temperatures 

 of 104 to 107° F; small, superficial, red 

 spots and papules on skin at site of inocu- 

 lation; local infiltration of tissues with 

 endothelial leucocytes, swelling of in- 

 volved epithelial cells ; nuclear inclusions 

 present in endothelial leucocytes and 

 some other cells ; disease not fatal ; virus 

 in circulating blood only during early 

 stages; recovery in a few days without 

 scar formation but with development of 

 specific immunity. The course of the 

 natural disease, presumed to occur in 

 rabbits, is still unknown. 



Transmission : Experimentally, by in- 

 jection of filtrates from diseased tissues; 

 on several occasions also from blood or 

 tissues of apparently normal rabbits. 



Serological relationships : Specific neu- 

 tralizing substances occur in the serum 

 of recovered rabbits. 



Immunological relationships : Specific 

 immunity but no cross reactions with 

 vaccinia or herpes viruses. 



Thermal inactivation : In 10 minutes at 

 55° C, but not in 30 minutes at 45° C. 



Filterability : Passes Berkefeld V and 

 N filters; passes L2 filter candle. 



Other properties : Viable at least 6 



