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MANUAL OF DETERMINATIVE BACTERIOLOGY 



FAMILY VI. RABULACEAE FAM. NOV. 



Viruses of the Mumps Group, characterized in general by a special affinity for ( issues 

 of the salivary glands. There is a single genus, 



Genus I. Rabula gen. nov. 



With characters of the family. Generic name from Latin rabula, pettifogger. 

 The type species is Rabula inflans spec. nov. 



Key to species of the genus Rabula. 



I. Affecting man. 



1. Rabula inflans. 

 II. Affecting guinea pig. 



2. Rabula Levis. 



III. Affecting hamster. 



3. Rabula innocuus. 



IV. Affecting rat. 



4. Rabula exiguus. 

 V. Affecting mouse. 



5. Rabula latens. 



1. Rabula inflans spec. nov. From 

 Latin inflare, to puff up. 



Common names : Mumps virus, virus 

 of epidemic parotitis. 



Hosts : HOM I N I D AE—Homo sapiens 

 L., man. Experimentally, also CERCO- 

 PITHECIDAE—Macaca mulatta (Zim- 

 mermann), rhesus monkeJ^ FELIDAE 

 — Felis caius L., domestic cat. 



Geographical distribution : World-wide. 



Induced disease : In man, in order of 

 frequency, parotitis, orchitis, meningo- 

 encephalitis, pancreatitis, or ovaritis; 

 rarely fatal ; when parotitis occurs, onset 

 is sudden, with pain in one or both parotid 

 glands, sometimes also with involvement 

 of submaxillary and sublingual glands, 

 swelling and malaise gradually disappear- 

 ing within a week or 10 days ; there is 

 virus in saliva 48 hours after onset ; orchi- 

 tis, less common, is usually unilateral and 

 may be accompanied by some epididymi- 

 tis. In rhesus monkej', experimentally, 

 acute, non-suppurative parotitis; focal 

 necrosis in acinar epithelial cells of 

 parotid gland, and secondary inflamma- 

 tion; dissemination of lesions within the 

 gland, enlargement of gland to palpation 

 and pitting edema of jowl 6 to 8 days after 

 inoculation, often with a rise of tempera- 



ture; cytoplasmic inclusion bodies in 

 affected glands, staining pink, round or 

 oval, 3 to 10 microns in diameter, often 

 vacuolate, usually surrounded by a nar- 

 row clear zone in the cytoplasm; blood 

 and uninoculated salivary gland of af- 

 fected animal not effective sources of 

 virus. 



Transmission : Probably by droplets 

 arising directly from infected individuals. 

 E.xperimentally, by injecting sterile 

 fluids containing virus into Stenson's 

 duct of parotid gland in Macaca mulatta. 



Serological relationships : A specific 

 complement -fixing antibody occurs in 

 human and monkey convalescent serum 

 and is demonstrable by the use of mon- 

 key-gland antigen. 



Immunological relationships : Specific 

 immunity induced by attack; passive 

 immunization rarely successful. 



Thermal inactivation : At 55° C in 1 

 hour. 



Filterability : Passes Berkefeld V and 

 N filter candles. 



Other properties : Viable in 50 per cent 

 glycerine at 2° C at least 5 weeks, in 50 

 per cent glycerine at 10° C. at least 7 

 weeks, dried while frozen at least 7 weeks, 

 in frozen saliva at least 3 weeks. 



