Brill and Williams: A Specific for Leprosy 



213 



67° to 68 c C. The properties of these acids are tabulated in 

 Table IV. When the residue of acids after the separation by 

 means of crystallization from alcohol was treated with barium 

 acetate, four fractions were obtained. These had the melting 

 points noted in Table IV. 



Table IV. — Melting point of acids obtained 

 acetate. 



treatment with barium 





Sample No.— 





2 



5 





°C. 

 36-37 

 40-41 

 39-40 



°C. 



47-48 

 38-39 

 39-40 









37-38 1 34-35 









Note. — Fractions 2 and 3 were in both cases united, and the combined portions were 

 reerystallized from alcohol, discarding the portion first crystallizing out. They were then 

 again converted into the barium salts, the acids set free, and again crystallized from alcohol. 

 The melting points correspond to the melting point of hydnocarpic acid, 59° to 60° C. 



Table V. — Saponification values of acids isolated from chaulmoogra oil. 



Sample. 



O.liVbase 



1 required 



Quantity.' f or neu . 



| traliza- 



tion. 



Saponi- 

 fication 

 value. » 





g. cc. 



200.5 

 202. 4 

 222.7 

 218.2 





1. 0587 

 1. 9205 

 2.8560 



38.13 

 76.21 

 110. 82 









"Theoretical saponification value for chaulmoogric acid, C n H 31 COOH = 200.5 ; for hydno- 

 carpic acid, C, 6 Hi, COOH = 222.7. 



Table VI.— Specific rotation in chloroform at 30° C/D of acids isolated 

 from chaulmoogra oil. 



Sample. 



Quantity 

 in 25 cc. 

 chloro- 

 form. 



Rotation 

 in cm. 



tube. 



Specific 

 rotation. * 



Chaulmoogric acid: 



a- 



1. 8120 



1.4416 



2. 6740 

 1.5545 



Degrees. 



+2.14 

 + 1.68 



+7.24 



Degrees. 



+59.05 

 +58. 10 



+67.70 



5...- __ . 



Hydnocarpic acid: 



2. 



5 









Found by Power for chaulmoogric acid, 58.6° ; for hydnocarpic acid, 68.1°. 



