PREVENTION, SYMPTOMS AND TREATMENT 223 



tion in the rabbit after inoculation of the brain is twelve to twenty- 

 one days; in the dog, fourteen to seventeen days after injection into 

 the eye. 



When a case of rabies occurs in a locality all dogs should be 

 muzzled for six months within a radius of twenty miles. Animals 

 bitten by rabid dogs should be killed. Dogs found loose without 

 muzzles should be impounded or, if this is impossible, shot. If per- 

 sons are bitten by rabid animals the bites should be at once freely 

 excised or thoroughly cauterized with strong nitric acid or a hot iron 

 and receive antiseptic irrigation and applications. Such persons 

 should then be sent to the nearest Pasteur institute for treatment or 

 be treated at home by attenuated virus procured from the Pasteur 

 institute in New York, or other large city, or from the Surgeon 

 General by application of any public health officer to the U. S. Pub- 

 lic Health and Marine Hospital Service at Washington, D. C. 

 Treatment is performed by injecting daily for a period of fifteen to 

 twenty-one days an attenuated virus of increasing intensity with 

 short period of incubation, and is free from danger and successful in 

 99 per cent, of cases treated within a comparatively short time after 

 receiving a bite from a rabid animal. It may be safe to wait for the 

 result of inoculation experiments as above, before sending bitten 

 persons for the Pasteur treatment, unless the bites have been in- 

 flicted on uncovered parts of the body. But if the clinical history 

 and autopsy are extremely suggestive of rabies the writer has sent 

 the bitten persons at once for treatment and has never had cause to 

 regret his action. The discovery of Negri bodies should lead to 

 immediate Pasteur treatment. No treatment is known which will 

 cure rabies in animals, or the same disease in man (hydrophobia), 

 when it has once appeared clinically. 



Rachitis — Rickets. 



A disease of all young animals — more common in pigs and 

 dogs — ail d characterized by faulty nutrition, digestive disorders, 



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