﻿66 
  DR 
  ANDERSON 
  ON 
  CODEINE, 
  AND 
  

  

  10-050 
  grains 
  of 
  the 
  crystallised 
  oxalate 
  lost, 
  at 
  212°, 
  0*704 
  grains 
  of 
  

   water 
  = 
  7*00 
  per 
  cent., 
  corresponding 
  to 
  three 
  equivalents 
  of 
  water, 
  which 
  re- 
  

   quires 
  7-27 
  per 
  cent. 
  The 
  formula 
  of 
  the 
  crystallised 
  salt 
  is, 
  therefore, 
  C 
  36 
  H 
  21 
  NO 
  c 
  . 
  

   HOC 
  2 
  3 
  + 
  3HO. 
  

  

  Hydrosulphocyanate 
  of 
  Codeine. 
  — 
  This 
  salt 
  has 
  been 
  already 
  examined 
  by 
  

   Dollfus 
  ;* 
  but 
  I 
  have 
  prepared 
  it, 
  and 
  repeated 
  the 
  analysis, 
  with 
  results 
  differ- 
  

   ing 
  somewhat 
  from 
  those 
  obtained 
  by 
  him. 
  It 
  is 
  readily 
  obtained 
  by 
  mixing 
  

   solutions 
  of 
  hydrochlorate 
  of 
  codeine 
  and 
  of 
  sulphocyanide 
  of 
  potassium, 
  and 
  is 
  

   slowly 
  deposited 
  in 
  beautiful 
  radiated 
  needles. 
  

  

  ( 
  6*164 
  grains 
  of 
  hydrosulphocyanate, 
  dried 
  at 
  212°, 
  gave 
  

   14-285 
  ••• 
  carbonic 
  acid, 
  and 
  

   3-543 
  ••• 
  water. 
  

  

  7.444 
  grains, 
  burnt 
  with 
  nitre 
  and 
  carbonate 
  of 
  soda, 
  gave 
  4-899 
  grains 
  of 
  

   sulphate 
  of 
  baryta. 
  

  

  These 
  results 
  correspond 
  with 
  the 
  formula 
  C 
  3G 
  H 
  21 
  NO 
  G 
  H 
  C 
  2 
  N 
  S 
  2 
  , 
  as 
  is 
  shewn 
  

   by 
  the 
  following 
  per 
  centage 
  calculation, 
  to 
  which 
  I 
  have 
  added 
  the 
  results 
  

   obtained 
  by 
  Dollfus 
  : 
  — 
  

  

  Experiment. 
  Calculation. 
  

  

  ^ 
  — 
  . 
  

  

  63-68 
  C 
  38 
  228 
  

  

  6-14 
  H 
  22 
  22 
  

  

  7-82 
  N 
  2 
  28 
  

  

  13-43 
  O 
  e 
  48 
  

  

  8-93 
  S 
  2 
  32 
  

  

  

  Dollfus. 
  

  

  

  Carbon, 
  

  

  62-30 
  

  

  63-20 
  

  

  Hydrogen, 
  

   Nitrogen, 
  

  

  6-13 
  

  

  6-38 
  

  

  Oxygen, 
  

   Sulphur, 
  

  

  : 
  ::: 
  

  

  9-04 
  

  

  100-00 
  358 
  

  

  11-613 
  grains 
  of 
  the 
  crystallised 
  salt, 
  dried 
  at 
  212°, 
  lost 
  0*288 
  grains 
  of 
  water 
  

   =2-47 
  per 
  cent., 
  corresponding 
  to 
  one 
  equivalent 
  of 
  water, 
  the 
  calculation 
  of 
  

   which 
  gives 
  2-45 
  per 
  cent. 
  

  

  In 
  the 
  analysis 
  of 
  Dollfus, 
  there 
  is 
  manifestly 
  a 
  loss 
  of 
  carbon, 
  as 
  the 
  results 
  

   are 
  quite 
  incompatible 
  with 
  those 
  of 
  the 
  base 
  and 
  its 
  other 
  salts. 
  In 
  the 
  same 
  

   paper 
  Dollfus 
  has 
  also 
  determined 
  the 
  amount 
  of 
  sulphocyanogen 
  by 
  precipitation 
  

   with 
  silver, 
  and 
  the 
  results 
  obtained 
  agree 
  better 
  with 
  the 
  formula 
  given 
  above 
  

   than 
  with 
  his 
  own. 
  

  

  Chloride 
  of 
  Platinum 
  and 
  Codeine. 
  — 
  When 
  bichloride 
  of 
  platinum 
  is 
  added 
  to 
  

   a 
  moderately 
  concentrated 
  solution 
  of 
  hydrochlorate 
  of 
  codeine, 
  a 
  pale-yellow, 
  

   pulverulent 
  precipitate 
  is 
  deposited. 
  If 
  this 
  be 
  allowed 
  to 
  stand 
  for 
  some 
  time 
  

   in 
  the 
  solution, 
  or 
  still 
  better, 
  if 
  it 
  be 
  collected 
  on 
  a 
  filter 
  and 
  kept 
  moist, 
  it 
  begins 
  

   to 
  change 
  in 
  its 
  appearance 
  ; 
  specks 
  of 
  darker 
  colour 
  appear 
  in 
  it, 
  and 
  it 
  is 
  gra- 
  

   dually 
  converted 
  into 
  a 
  mass 
  of 
  crystalline 
  grains 
  of 
  an 
  orange-yellow 
  colour. 
  

   The 
  fluid 
  which 
  filters 
  off 
  deposits, 
  on 
  standing, 
  a 
  small 
  quantity 
  of 
  larger 
  grains. 
  

  

  * 
  Annalen 
  der 
  Chimie 
  und 
  Pharmacie, 
  vol. 
  lxv., 
  p. 
  218. 
  

  

  