﻿ITS 
  PKODUCTS 
  OF 
  DECOMPOSITION. 
  

  

  73 
  

  

  Considerable 
  difficulty 
  was 
  experienced 
  in 
  getting 
  it 
  absolutely 
  free 
  from 
  co- 
  

   deine 
  ; 
  and 
  the 
  first 
  of 
  the 
  following 
  analyses 
  has 
  given 
  an 
  excess 
  in 
  the 
  carbon 
  : 
  — 
  

  

  {6-119 
  grains 
  bromocodeine, 
  dried 
  at 
  212°, 
  gave 
  

   12*941 
  ••• 
  of 
  carbonic 
  acid, 
  and 
  

   3-000 
  ••• 
  of 
  water. 
  

  

  f 
  5- 
  

  

  II. 
  \ 
  12- 
  

  

  I 
  2- 
  

  

  940 
  grains 
  bromocodeine 
  gave 
  

   461 
  ... 
  of 
  carbonic 
  acid, 
  and 
  

   910 
  ••• 
  of 
  water. 
  

  

  5-268 
  grains 
  gave 
  2-663 
  grains 
  of 
  bromide 
  of 
  silver. 
  

  

  

  Experiment. 
  

  

  

  Calculation. 
  

  

  

  

  I. 
  

  

  II. 
  

  

  

  

  ~-^ 
  

  

  Carbon, 
  

  

  57-67 
  

  

  57-21 
  

  

  57-14 
  

  

  C 
  36 
  

  

  216 
  

  

  Hydrogen, 
  . 
  

  

  5-44 
  

  

  5-44 
  

  

  5-29 
  

  

  ■^20 
  

  

  20 
  

  

  Bromine, 
  

  

  

  21-50 
  

  

  2116 
  

  

  Br 
  

  

  80 
  

  

  Nitrogen, 
  . 
  

  

  

  ... 
  

  

  3-70 
  

  

  N 
  

  

  14 
  

  

  Oxygen, 
  . 
  

  

  

  ... 
  

  

  12-71 
  

  

  o 
  6 
  

  

  48 
  

  

  100-00 
  

  

  378 
  

  

  The 
  formula 
  is 
  therefore 
  C 
  36 
  H 
  20 
  Br 
  N0 
  6 
  . 
  Bromocodeine 
  is 
  capable 
  of 
  uniting 
  

   with 
  water 
  in 
  two 
  different 
  proportions, 
  as 
  appears 
  by 
  the 
  determination 
  of 
  the 
  

   loss 
  by 
  drying. 
  

  

  11-784 
  crystallised 
  bromocodeine, 
  lost 
  at 
  212° 
  0-273, 
  =2-32 
  per 
  cent. 
  

   9-308 
  ... 
  ... 
  ... 
  0-623, 
  =6-69 
  ... 
  

  

  7-707 
  ... 
  ... 
  ... 
  0-512, 
  =6-64 
  ... 
  

  

  The 
  first 
  of 
  these 
  results 
  corresponds 
  exactly 
  to 
  one 
  equivalent 
  of 
  water, 
  the 
  

   calculated 
  result 
  for 
  which 
  gives 
  232 
  per 
  cent. 
  The 
  other 
  two 
  give 
  three 
  equi- 
  

   valents, 
  for 
  which 
  the 
  calculation 
  is 
  6- 
  66. 
  I 
  am 
  unable 
  now 
  to 
  recollect 
  how 
  

   the 
  bromocodeine 
  used 
  in 
  the 
  first 
  experiment 
  was 
  obtained, 
  but 
  my 
  impression 
  

   is, 
  that 
  it 
  was 
  prepared 
  in 
  exactly 
  the 
  same 
  manner 
  as 
  the 
  rest. 
  

  

  Hydrochlorate 
  of 
  Bromocodeine 
  is 
  obtained 
  in 
  radiated 
  needles 
  closely 
  re- 
  

   sembling 
  those 
  of 
  hydrochlorate 
  of 
  codeine. 
  

  

  Hydrobromate 
  of 
  Bromocodeine. 
  — 
  The 
  crystals, 
  which 
  have 
  been 
  mentioned 
  

   as 
  making 
  their 
  appearance 
  during 
  the 
  preparation 
  of 
  bromocodeine, 
  are 
  this 
  

   salt. 
  It 
  is 
  sparingly 
  soluble 
  in 
  cold 
  water, 
  readily 
  soluble 
  in 
  boiling 
  water, 
  and 
  

   is 
  deposited 
  from 
  the 
  solution 
  in. 
  small 
  prismatic 
  crystals. 
  It 
  contains 
  two 
  equi- 
  

   valents 
  of 
  water 
  which 
  are 
  not 
  expelled 
  at 
  212°. 
  

  

  {8-424 
  grains 
  of 
  hydrobromate, 
  dried 
  at 
  212°, 
  gave 
  

   13-956 
  ■•• 
  of 
  carbonic 
  acid, 
  and 
  

   3-985 
  ••• 
  of 
  water. 
  

  

  

  Experiment. 
  

  

  45-18 
  

  

  

  Calculation. 
  

  

  

  Carbon, 
  

  

  45-28 
  

  

  ^36 
  

  

  216 
  

  

  Hydrogen, 
  

  

  5-25 
  

  

  4-84 
  

  

  H 
  23 
  

  

  23 
  

  

  Bromine, 
  

  

  . 
  

  

  33-54 
  

  

  Br 
  2 
  

  

  160 
  

  

  Nitrogen, 
  

  

  . 
  

  

  2-93 
  

  

  N 
  

  

  14 
  

  

  Oxygen, 
  

  

  . 
  

  

  13-41 
  

  

  o 
  8 
  

  

  64 
  

  

  100-00 
  

  

  477 
  

  

  VOL. 
  XX. 
  PART 
  I. 
  

  

  U 
  

  

  