﻿74 
  DR 
  ANDERSON 
  ON 
  CODEINE, 
  AND 
  

  

  The 
  formula 
  of 
  the 
  salt 
  is 
  therefore 
  C, 
  e 
  H, 
  n 
  Br 
  NO, 
  H 
  Br 
  + 
  2 
  HO. 
  

   Platinochloride 
  of 
  Bromocodeine 
  is 
  precipitated 
  as 
  a 
  pale-yellow 
  powder, 
  

   insoluble 
  in 
  water 
  and 
  alcohol. 
  

  

  8-126 
  grains, 
  dried 
  at 
  212°, 
  gave 
  1*380 
  grains 
  platinum. 
  

  

  Carbon, 
  

  

  Hydrogen, 
  

  

  Bromine, 
  

  

  Nitrogen, 
  

  

  Oxygen, 
  

  

  Chlorine, 
  

  

  Platinum, 
  

  

  Experiment. 
  

  

  

  Calculation. 
  

  

  

  ... 
  

  

  36-97 
  

  

  ^36 
  

  

  216 
  

  

  ... 
  

  

  3-59 
  

  

  -^20 
  

  

  20 
  

  

  ... 
  

  

  13-70 
  

  

  Br 
  

  

  80 
  

  

  ... 
  

  

  2-39 
  

  

  N 
  

  

  14 
  

  

  ... 
  

  

  5-23 
  

  

  6 
  

  

  48 
  

  

  ... 
  

  

  18-23 
  

  

  CI 
  

  

  106-5 
  

  

  16-98 
  

  

  16-89 
  

  

  Pt 
  

  

  98-7 
  

  

  100-00 
  584-2 
  

  

  Tribromocodeine. 
  — 
  By 
  continuing 
  the 
  addition 
  of 
  bromine 
  water 
  beyond 
  the 
  

   point 
  at 
  which 
  bromocodeine 
  is 
  formed, 
  a 
  further 
  action 
  takes 
  place, 
  and 
  a 
  bright- 
  

   yellow 
  precipitate 
  makes 
  its 
  appearance, 
  which 
  at 
  first 
  redissolves 
  in 
  the 
  fluid, 
  

   but 
  after 
  a 
  time 
  becomes 
  permanent, 
  and 
  goes 
  on 
  gradually 
  increasing 
  until 
  a 
  very 
  

   large 
  quantity 
  of 
  bromine 
  has 
  been 
  employed, 
  when 
  at 
  length 
  a 
  point 
  is 
  reached 
  

   at 
  which 
  no 
  further 
  precipitate 
  is 
  produced. 
  If 
  the 
  solution 
  be 
  left 
  till 
  next 
  day, 
  

   however, 
  bromine 
  again 
  causes 
  a 
  precipitate 
  ; 
  and 
  if 
  it 
  be 
  added, 
  as 
  long 
  as 
  anything 
  

   falls, 
  and 
  the 
  solution 
  be 
  again 
  left 
  standing, 
  another 
  precipitate 
  is 
  produced 
  iden- 
  

   tical 
  in 
  all 
  respects 
  with 
  that 
  before 
  obtained, 
  and 
  this 
  may 
  be 
  repeated 
  day 
  after 
  

   day 
  for 
  a 
  very 
  considerable 
  time. 
  The 
  yellow 
  precipitate 
  so 
  obtained 
  is 
  the 
  hydro- 
  

   bromate 
  of 
  tribromocodeine. 
  It 
  is 
  collected 
  on 
  a 
  filter, 
  and 
  washed 
  with 
  water, 
  in 
  

   which 
  it 
  is 
  very 
  sparingly 
  soluble. 
  In 
  order 
  to 
  obtain 
  the 
  base, 
  this 
  substance 
  is 
  

   dissolved 
  in 
  dilute 
  hydrochloric 
  acid 
  and 
  ammonia 
  added, 
  when 
  the 
  tribromoco- 
  

   deine 
  is 
  immediately 
  precipitated 
  as 
  a 
  flocky 
  powder, 
  which 
  is 
  washed 
  with 
  water, 
  

   and 
  purified 
  by 
  solution 
  in 
  alcohol, 
  and 
  precipitation 
  with 
  water. 
  

  

  Tribromocodeine 
  is 
  thus 
  obtained 
  as 
  a 
  bulky 
  white 
  precipitate, 
  perfectly 
  amor- 
  

   phous, 
  and 
  when 
  dry, 
  more 
  or 
  less 
  gray 
  in 
  its 
  colour. 
  It 
  is 
  insoluble 
  in 
  water 
  

   and 
  ether, 
  but 
  readily 
  soluble 
  in 
  alcohol. 
  It 
  is 
  sparingly 
  soluble 
  in 
  hydrochloric 
  

   acid 
  in 
  the 
  cold, 
  but 
  much 
  more 
  so 
  by 
  boiling. 
  In 
  this 
  process, 
  however, 
  it 
  ap- 
  

   pears 
  to 
  undergo 
  a 
  partial 
  decomposition, 
  as 
  a 
  small 
  quantity 
  is 
  always 
  left 
  in- 
  

   soluble. 
  Heated 
  on 
  platinum 
  foil 
  it 
  becomes 
  brown, 
  and 
  is 
  entirely 
  decomposed 
  

   at 
  its 
  melting 
  point, 
  leaving 
  a 
  coal 
  difficult 
  of 
  incineration. 
  

  

  The 
  tribromocodeine 
  employed 
  for 
  analysis 
  was 
  purified 
  by 
  a 
  second 
  solution 
  

   in 
  alcohol, 
  and 
  precipitation 
  by 
  ether. 
  It 
  gave 
  the 
  following 
  results 
  : 
  — 
  

  

  {8-014 
  grains 
  of 
  tribromocodeine, 
  dried 
  at 
  212°, 
  gave 
  

   11-665 
  ... 
  of 
  carbonic 
  acid, 
  and 
  

   2-645 
  ••• 
  of 
  water. 
  

  

  3-55 
  grains 
  of 
  tribromocodeine 
  gave 
  3 
  - 
  727 
  grains 
  bromide 
  of 
  silver. 
  

  

  