﻿78 
  

  

  DR 
  ANDERSON 
  ON 
  CODEINE, 
  AND 
  

  

  The 
  crystallised 
  base 
  contains 
  water 
  which 
  is 
  expelled 
  at 
  212°. 
  

  

  7'67 
  grains 
  chlorocodeine 
  lost 
  0-551 
  grains 
  water, 
  =7'18 
  per 
  cent. 
  

   9-82 
  0-740 
  ••• 
  =7-53 
  ... 
  

  

  The 
  calculated 
  number 
  for 
  three 
  equivalents 
  of 
  water 
  is 
  7*48 
  per 
  cent. 
  ; 
  and 
  

   the 
  formula 
  of 
  the 
  crystallised 
  base 
  is 
  therefore 
  C 
  ?6 
  H, 
  n 
  CI 
  N0 
  6 
  + 
  3 
  HO. 
  

  

  The 
  salts 
  of 
  chlorocodeine 
  are 
  exactly 
  similar 
  in 
  their 
  properties 
  to 
  those 
  of 
  

   bromocodeine 
  ; 
  so 
  much 
  so, 
  that 
  I 
  have 
  not 
  thought 
  it 
  necessary 
  to 
  examine 
  more 
  

   than 
  one 
  or 
  two 
  of 
  them. 
  

  

  Hydrochlorate 
  of 
  Chlorodeine. 
  — 
  Crystallises 
  in 
  groups 
  of 
  needles, 
  readily 
  so- 
  

   luble 
  in 
  water. 
  

  

  Sulphate 
  of 
  Chlorocodeine 
  is 
  deposited 
  from 
  its 
  hot 
  solution 
  in 
  radiated 
  

   groups 
  of 
  short 
  prisms, 
  which 
  dissolve 
  abundantly 
  in 
  boiling 
  water 
  and 
  alcohol. 
  

  

  10-874 
  grains 
  of 
  the 
  crystallised 
  salt, 
  dried 
  at 
  212°, 
  gave 
  0-953 
  grains 
  of 
  water, 
  

   and 
  3 
  078 
  grains 
  of 
  sulphate 
  of 
  baryta. 
  

  

  Chloi'ocodeine, 
  

   Sulphuric 
  acid, 
  

   Water, 
  

  

  Experiment. 
  

  

  79-34 
  

  

  11-90 
  

  

  8-76 
  

  

  100-00 
  

  

  Calculation. 
  

  

  79-63 
  

   11-75 
  

   8-662 
  

  

  100-00 
  

  

  Base. 
  

   HOS0 
  3 
  

   4 
  HO 
  

  

  333-5 
  

   49-0 
  

   360 
  

  

  418-5 
  

  

  Platinochloride 
  of 
  Chlorocodeine 
  is 
  obtained 
  in 
  the 
  usual 
  way, 
  as 
  a 
  pale- 
  

   yellow 
  precipitate 
  scarcely 
  soluble 
  in 
  water. 
  Its 
  analysis 
  gave 
  the 
  following 
  

   results 
  : 
  — 
  

  

  {7'212 
  grains 
  platinochloride, 
  dried 
  at 
  212°, 
  gave 
  

   10658 
  ••• 
  of 
  carbonic 
  acid, 
  and 
  

   2-655 
  ••• 
  of 
  water. 
  

  

  8-793 
  grains 
  platinochloride 
  gave 
  1-608 
  grains 
  platinum. 
  

  

  

  Experiment. 
  

   40-30 
  

  

  

  Calculation. 
  

  

  

  Carbon, 
  

  

  40-02 
  

  

  ^36 
  

  

  216 
  

  

  Hydrogen, 
  

   Nitrogen, 
  

  

  4-09 
  

  

  3-89 
  

   2-59 
  

  

  H 
  21 
  

  

  N 
  

  

  21 
  

   14 
  

  

  Oxygen, 
  

   Chlorine, 
  

  

  . 
  

  

  8-91 
  

   26-31 
  

  

  Cl 
  4 
  

  

  48 
  

   142 
  

  

  Platinum, 
  

  

  18-29 
  

  

  18-28 
  

  

  Pt 
  

  

  98-7 
  

  

  100-00 
  

  

  539-7 
  

  

  VII. 
  Action 
  of 
  Cyanogen 
  on 
  Codeine. 
  

  

  Dicyanocodeine. 
  — 
  When 
  a 
  current 
  of 
  cyanogen 
  is 
  passed 
  into 
  a 
  solution 
  of 
  

   codeine 
  in 
  the 
  smallest 
  possible 
  quantity 
  of 
  alcohol, 
  the 
  gas 
  is 
  rapidly 
  absorbed, 
  

   and 
  the 
  fluid 
  acquires, 
  first 
  a 
  yellow, 
  and, 
  by 
  continued 
  action, 
  a 
  brown 
  colour. 
  

   If 
  the 
  solution 
  be 
  then 
  left 
  to 
  itself 
  for 
  some 
  time, 
  the 
  smell 
  of 
  cyanogen 
  disappears, 
  

  

  