CRYSTALLINE CONSTITUENTS OF OPIUM. 



201 



Bromopapaverine itself is easily obtained from this substance, by digesting it 

 with ammonia, and dissolving the product in boiling alcohol. It is deposited, on 

 cooling, in minute white needles, insoluble in water, but readily soluble both in 

 alcohol and ether. It dissolves in the acids and forms salts, the greater number 

 of which are characterized by their sparing solubility. Its crystals were anhy- 

 drous, and gave on analysis the subjoined results,— 



{5 "16 8 grains bromopapaverine gave 

 10-845 ... carbonic acid, and 

 2-335 ... water. 



[ 4-780 grains, dried at 212°, gave 

 (_ 2*185 ... bromide of silver. 



These results correspond with the formula C 40 H 20 BrN0 8 , as is obvious from the 

 calculation given below. 





Experiment. 



5723 



( 



Calculation. 





Carbon, 



57*41 



C40 



240 



Hydrogen, . 



5-02 



4-78 



H 20 



20 



Nitrogen, 



. 



3-34 



N 



14 



Oxygen, 





15-34 



° 8 



64 



Bromine, 



19-45 



19-13 



Br 



80 



100-00 



4-18 



Hydrdbromate of Bromopapaverine. — This salt is obtained, as already men- 

 tioned, by the addition of bromine water to a solution of hydrochlorate of papa- 

 verine. It varies somewhat in its appearance, according to the degree of concen- 

 tration of the solution from which it is obtained. If concentrated, it is deposited 

 with a more or less yellow colour, and is apt to form resinous lumps, particularly 

 if the bromine water is added rapidly ; but when the solutions are more dilute, 

 it appears in the form of a perfectly white powder. It is well washed with water, 

 dissolved in boiling spirit, and on cooling is deposited in a state of purity in the 

 form of a crystalline powder, insoluble in water, and sparingly soluble in alcohol. 

 When gently heated it melts, and is decomposed. When digested with potash 

 or ammonia, it is decomposed, with separation of the base. Its crystals are anhy- 

 drous, and gave the following results on analysis : — 



f 5-647 grains, dried at 212°, gave 

 10-015 ... carbonic acid, and 

 2-215 ... water. 





{ 



6-398 



grains, dried at 212° 



gave 









4-883 



bromide of silver. 













Experiment. 



48-36 





Calculation. 





Carbon, . 



48-09 



C 40 



240 



Hydrogen, 





. 



4-35 



4-20 



H 21 



21 



Nitrogen, 





. 





2-80 



N 



14 



Oxygen, 





. 





12-85 



o 8 



64 



Bromine, 





• 



32-48 



32-06 



Br 2 



160 



100-00 



499 



