202 DR T. ANDERSON ON SOME OF THE 



corresponding with the formula 



C 40 H 20 BrNO 8 + HBr. 



Hydrochlorate of Bromopapaxerine — is soluble in water, though sparingly. 

 The rest of its salts have not been examined. 



Action of Chlorine on Papaverine. 



When a current of chlorine is passed through a solution of hydrochlorate of 

 papaverine, the fluid becomes brown, and after a time a dirty gray precipitate 

 makes its appearance, which is insoluble, or nearly so, in water, but dissolves in 

 boiling alcohol, and gives a resinous deposit as the solution cools. When treated 

 with ammonia, hydrochloric acid is separated, and a powder is obtained which 

 is obviously chlorine base. It dissolves in the acids, and is reprecipitated by am- 

 monia. Alcohol takes it up, and deposits it in an amorphous form on cooling or 

 by spontaneous evaporation. The properties of this substance proving unsatis- 

 factory, I then tried the action of chlorate of potass added in small successive 

 portions to a solution of papaverine in excess of hydrochloric acid, but the same 

 amorphous gray powder being produced, I did not pursue the subject further; 

 for although one or more derivative bases are unquestionably produced, their 

 properties are not sufficiently well marked to admit of their proper purification. 



Action of Iodine on Papaverine. 



When an alcoholic solution of papaverine is mixed with tincture of iodine, and 

 the solution is left to itself for some hours, small crystals are slowly deposited, 

 and by further evaporation of the fluid from which they have been removed, ano- 

 ther substance is obtained. 



Teriodide of Papaverine. — To the crystals first separated I give this name. 

 They are purified by solution in boiling alcohol, from which they are slowly de- 

 posited in small rectangular prisms. Their colour is purple by reflected, and dark 

 red by transmitted light. They are insoluble in water, but soluble in alcohol. 

 It is not acted upon by dilute acids, but ammonia and potash rapidly decompose 

 it, removing iodine, and leaving papaverine. From this fact it is clear that it is 

 not the salt of a substitution base, but corresponds in constitution with the 

 teriodide of codeine, which I described in a former paper.* Analysis gave the 

 subjoined results : — 



{7 - 065 grains teriodide of papaverine, dried at 212°, gave 

 8-550 ... carbonic acid, and 

 2-045 ... water. 



f 7'650 grains teriodide of papaverine gave 

 \ 7'489 . . . iodide of silver. 



* Edinburgh New Philosophical Journal, vol. I., p. 103. 



