738 DR FRASER ON THE PHYSIOLOGICAL ACTION 



In 40 minutes, reflex movement occurred in 80 beats. 

 50 „ „ 101 „ 



1 hour and 5 minutes ,, 118 „ 



1 „ 15 „ „ 136 „ 



1 „ 20 „ „ 150 ., 



1 „ 30 „ „ 200 „ 



1 „ 40 „ no movement in 200 ,, 



A stronger acid was substituted (20 min. to 12 oz.). 



In 1 hour and 50 minutes, reflex movement in 111 beats. 



2 hours 







160 



is 



2 „ 



10 



173 



!) 



2 



20 



198 



n 



2 



30 



„ no reflex movement in 220 



n 



2 „ 



35 



.. strong acid caused no reflex movement 



The heart was exposed ; and it was found contracting in proper rhythm, nineteen times per 

 minute. The sciatic nerves were active. 



On the following day, the heart was contracting twenty times per minute ; and galvanism 

 of the sciatic nerves caused feeble muscular contractions in the posterior extremities, but no 

 diastaltic movement. The frog ultimately died. 



Experiment XLI. 



After ligature of its left femoral artery and vein, a frog, weighing 495 grains, was suspended 

 as in the previous experiments. The reflex activity was tested with the following result : — 

 Metronome, 100 to 1 minute ; acid = 5 min. to 12 oz. water. 



At 20 minutes before poisoning, the left leg was drawn up in 24 beats. 

 15 „ „ right,, „ 19 „ 



5 „ „ left „ „ 28 „ 



Three grains of extract, in water, were then injected subcutaneously at the back. 



In 5 minutes, the right leg was drawn up in 24 beats. 



30 „ 



36 „ 



56 „ 



72 „ 



90 „ 



150 „ 



no movement when either foot was kept in contact with the acid 



during 200 beats. 



A stronger acid was substituted, of the strength of 10 minims of oil of vitriol to 12 oz. 

 of water. 



In 45 minutes, the right leg was drawn up in 89 beats. 

 50 „ left „ „ 104 „ 



55 „ right „ „ 108 „ 



1 hour left „ „ 172 „ 



A still stronger acid, 20 minims to 12 oz., was now used. 



In 1 hour 5 minutes, the right leg was drawn up in 85 beats. 



10 



>> 



left 



15 



>1 



right 



20 



>> 



left 



25 



)) 



right 



30 



>) 



left 



35 



J5 



right 



40 



5J 



no movei 



1 „ 10 „ left „ „ 118 



1 „ 15 „ right „ „ 138 



1 „ 20 „ left „ „ 140 



