756 



DR FRASER ON THE PHYSIOLOGICAL ACTION 



a. Arterial Tension only. 



Experiment LVI1I. 



A large and vigorous retriever dog was placed on a table, and tied down by its four limbs.* 



T 1 ! 





Time after 

 Adminis- 

 tration. 



Mean 



Pressure Oscil- 



No. of 

 Cardiac 



No, of 

 Respira- 

 tions. 



Notes of Operations and of 



-Limes. 



Pressure. 



lates between 



Contrac- 

 tions. 



Symptoms. 



H. M. 



s. 



M. s. 







Per Min. 



P rMin. 





3 16 



P.M. 



. . . 







• • • 



20 



The right carotid artery was ex- 

 posed and connected with the 

 nsemadynamometer. 



3 16 



30 





6-8 



5-2 & 90 









3 19 









70 



5-0 9-0 



86 



18 





3 20 



30 





6-9 



5-3 9-3 





18 





3 22 









7-2 



5-3 93 



108 



19 





3 24 









7-0 



51 89 









3 26 



20 













Two grains of extract, in forty 

 minims of distilled water, were 

 injected into the subcutaneous 

 tissue of the abdomen. 



3 26 



30 





68 



5-5 90 



102' 







3 26 



50 













The injection of the poison was 

 completed. 



3 29 







2 10 



6-9 



49 9-2 



93 



19 



Dog is perfectly quiet. 



3 33 







6 10 



6-8 



4-5 9-2 



90 



18 



A few struggles occurred. 



3 35 







8 10 



6-7 



4-9 8-5 



75 



17 





3 38 



30 



11 40 



7-5 



50 10-0 



90 



19 



Somewhat violent struggles. 



3 41 







14 10 



7-8 



5-5 93 



90 



15 



Muscular twitches over nearly all 

 the body. 



3 41 



30 



14 40 



8-0 







17 





3 42 







15 10 



8-4 



7-0 io-o 





21 



Muscular twitches have increased 

 in violence. 



3 43 







16 10 



89 



70 10-0 





22 





3 44 







17 10 



88 



7-5 10-4 









3 45 







18 10 



8-5 



7-0 9-3 



106 







3 46 







19 10 



8-3 



7-0 9-3 



104 



31 





3 48 







21 10 



8-2 



65 9-5 



98 



38 



Twitches are now much feebler; 

 greatlachrymation and salivation. 



3 50 







23 10 



815 



7-5 95 





9 





3 52 







25 10 



7-9 



6-5 9-4 



96 



40 





3 55 







28 10 



7-65 



65 9-9 



96 



37 





3 57 







30 10 



7-55 



6-5 8-6 





30 



Urine and faeces passed. 



3 58 







31 10 









34 



Respirations noisy, from mucus in 

 the trachea. 



3 59 







32 10 



7-3 



6-0 8-5 



100 



28 



Very fluid faeces passed. 



4 







33 10 



7-2 



63 8-5 



112 



25 





4 3 



30 



36 40 



71 



60 8-0 



112 



22 



The twitches have very much 

 diminished in force. 



* I have much pleasure in acknowledging the valuable assistance I derived in this series of experi- 

 ments from my friend, Dr Gamgee. I am also indebted, for essential aid in all or several of them, 

 to Dr Brunton, and to Messrs Paton, Ritchie, Finlay, Caton, Hogg. Holden, Wright, Hardie, 

 Gairdner, Glascott, Lucas, M'Ewan, Howieson, Crombie and Young. Without the co-opera- 

 tion of these gentlemen, it would have been quite impossible to obtain the many simultaneous observa- 

 tions which are contained in these experiments, and to which much of their value is due. 



