^58 



DR FRASER ON THE PHYSIOLOGICAL ACTION 



Experiment LVIII. — continued. 



T 



ime. 



Time after 

 Second 



Adminis- 

 tration. 



Mean 

 Pressure. 



Pressure Oscil- 

 lates between 



No. of 

 Cardiac 

 Contrac- 

 tions. 



No. of 

 Respira- 

 tions. 



Notes of Operations and of 

 Symptoms. 



H. M. 



4 52 



s. 

 



M. S. 



29 30 



7-2 



6-0 & 90 



Per Min. 



Per Min. 





4 53 







30 30 



71 



5-9 90 









4 54 







31 30 



6-3 



59 82 







t 



4 55 







32 30 



63 



5-0 80 



24 







4 55 



20 



32 50 



56 



4-0 80 









4 55 



30 



33 



61 



50 8-0 









4 56 







33 30 



50 



4-5 7-0 





21 





4 57 







34 30 



4-6 



3-5 5-8 



22 







4 57 



15 



34 45 



40 



3-5 5-5 









4 57 



30 



35 



4-4 



3-5 6-0 









4 58 

 4 59 





 



35 30 



36 30 



4-4 

 40 



3-0 6-0 

 30 5-0 





27 



The respirations are extremely 

 shallow and gasping. 



4 59 



30 



37 



35 



25 4-5 









5 







37 30 



25 



1-0 3-0 









5 

 5 1 



30 

 15 



38 

 38 45 



1-8 



1-6 



1-0 2-5 

 10 2-0 



18 



4 

 4 



Respirations are mere gasps. 



5 1 



30 



39 





10 1 5 







Mercurial column has fallen into 

 the reservoir. 



In the autopsy, which was immediately made, the heart was found dilated with dark blood. 

 Occasional contractions occurred for twenty minutes after death. The sciatic, intercostal and 

 phrenic nerves were active, and galvanism of a vagus nerve excited vermicular movements 

 of the stomach. The intestinal peristalsis was feeble. Galvanism of the cervical sympathetics 

 produced no contraction of the pupils. A quivering movement continued in the striped 

 muscles for many minutes. 



The first portion of this experiment shows that after the administration of the 

 poison a very distinct rise occurs in the arterial tension, while the number of 

 the cardiac contractions rapidly diminishes during this rise, and before the fre- 

 quency of the respirations has been affected. The second, and larger, dose did not 

 influence the arterial tension so powerfully, nor did it exert so immediate an action 

 on the frequency of the heart's beats. Both doses were administered in such a 

 manner that their absorption was comparatively slow ; in the following experi- 

 ments, physostigma was directly injected into the circulation, and its action was, 

 therefore, more rapidly and energetically produced. 



