768 



DR FRASER ON THE PHYSIOLOGICAL ACTION 



Action on the Temperature of the Body. 



The temperature of mammalians that are being poisoned by Calabar bean 



rises slightly, so that a thermometer, placed either in the subcutaneous tissue or 



in the rectum, will indicate a gradual elevation as soon as well-marked symptoms 



begin to be produced. The effect on the surface temperature has been already 



shown in Experiments LIX., LX. and LXI. ; that on the internal temperature 



was frequently observed with rabbits, and may be illustrated sufficiently in the 



following experiment. 



Experiment LXIV. 



A full-grown rabbit was placed on its back on a board, and firmly secured by a ligature 

 round each leg. 



Time. 



Time after 

 Administration 



Tempera- 



Respira- 



Notes. 







of Poison. 



ture. 



tions. 





H. 



M. 



M 



s. 





Per Min. 





12 



5 











The bulb of a delicate thermometer, with 

 Fahrenheit's scale, was secured in the 

 rectum. 



12 



10 







990 







12 



20 







98 5 







12 



30 







984 







12 



40 







982 







12 



50 







980 



47 





1 











97-5 







1 



10 







973 







1 



20 







970 



48 





1 



30 







965 







2 











960 



48 





o 



10 







95 8 







2 



20 







95-7 



48 





2 



30 







95-5 



48 





2 



40 







95 5 



48 





2 



50 







95-3* 



48 





2 



56 











Haifa grain of extract, in ten minims of 

 water, was injected into the subcu- 

 taneous tissue of the left flank. 



3 



1 



5 







95-8 





Faint tremors of legs and of head. 



3 



5 



9 







963 





Tremors are now general and stronger ; 

 and they prevent accurate determina- 

 tion of the respiratory movements. 



3 



6 



10 







965 







3 



8 



12 







96-0 







3 



15 



17 







95-5 







3 



16 



18 







953 



72 



The muscular tremors have greatly 

 diminished. Respirations are shallow 

 and gasping, and they appear much 

 impeded by bronchial secretion. 



3 



25 



29 







950 





Quiet ; except a few occasional twitches. 



3 



30 



34 







950 



24 



Respirations are very noisy and laboured. 



3 



32 



36 







94 5 





The animal is dead. 



3 



35 



39 







94-0 







3 



50 



54 







930 







* It will be observed that the temperature has gradually fallen in this experiment before the 



