PRODUCED BY ATROPIA IN COLD-BLOODED ANIMALS. 



463 



TABLE I. — Summary of Experiments on Frogs with Sulphate of Atropia, in which the 

 Effects were not materially interfered with by Operations or otherwise. 



Number 



of 



Experiment. 



In Grains. 



Weight 

 of Frog. 



Dose. 



Relation 

 of Dose 



to 

 Weight 

 of Frog. 



Region 



of 



Injection. 



Effect. 



I. 



II. 

 III. 

 IV. 

 V. 



VI.* 



VII. 

 VIII. 



IX. 



X. 



XI. 

 XII. 



XIII. 



XIV. 



413 

 275 

 333 

 294 

 298 



0-05 



0-05 



0-1 



0-1 



0-2 



?2 6 



1 



S500 



1 



3 3 3 



1 



If 9 4 



1 

 1190 



275 



0-2 



273 



0-2 



376 



03 



250 



0-2 



231 



0-2 



346 



0-3 



230 



0-2 



340 



0-3 



447 



0-4 



1 



136J 



12 5 3 



1 _ 



1~Z~5 



TTJ'S' 



1 



1153 



_ 1 



llJO 



Tl 33 



Under skin of 

 left flank. 



Into abdomi- 

 nal cavity. 



Under skin of 



left thigh. 



Do. 



Do. 



yJ^ Into abdomi- 

 nal cavity. 



Do. 



Do. 



Do. 



Under skin of 

 left flank. 



Into abdomi- 

 nal cavity. 

 Do. 



Under skin of 

 right flank. 



Do. 



No obvious effect. 



None observed in 6 hours. 



No obvious effect. 



Slight incomplete paralysis 1st day ; and per- 

 fect recovery 2d day. 



Incomplete paralysis 1st day; exaggerated reflex 

 movements 2d day ; tetanus 3d day ; and re- 

 covery 4th day. 



Incomplete paralysis 1st day ; tetanus 2d to 

 5th days ; stiff spasmodic reflex movements 

 6th to 8th days ; and perfect recovery 10th 

 day. 



Incomplete paralysis 1st day ; exaggerated re- 

 flex movements 2d to 5th days ; and recovery 

 6th day. 



Incomplete paralysis 1st to 3d days ; tonic 

 spasm and tetanus of anterior extremities and 

 chest muscles, with only slightly exaggerated 

 reflex movements of posterior extremities 4th 

 to 10th days ; and perfect recovery 12th day. 



Incomplete paralysis 1st day; tetanus 2d to 6th 

 days; stiff spasmodic reflex movements 7th 

 and 8th days ; and perfect recovery 9th day. 



Incomplete paralysis 1st day ; exaggerated re- 

 flex movements 2d and 3d days ; and perfect 

 recovery 5th day. 



Incomplete paralysis 1st to 8th days; and 

 death, with commencing rigor, 9th day. 



Incomplete paralysis 1st and 2d days; slight 

 tetanus 3d day ; stiff spasmodic reflex move- 

 ments 4th to 6th days; and recovery 7th day. 



Incomplete paralysis 1st day ; tetanus 2d day ; 

 stiff spasmodic reflex movements 3d day ; 

 and perfect recovery 5 th day. 



Incomplete paralysis 1st day ; spasms 2d day ; 

 incomplete paralysis 3d day ; tetanus 4th 

 to 6 th days ; stiff reflex movements 7th day ; 

 and recovery 8th day. 



* The same frog was used in this experiment as in Experiment II. The second dose (0 2 gr.) 

 was administered 21 hours after the first, and when the frog appeared to be in normal health. The 

 influence of the first dose might, however, have been still partially present ; and the exceptional 

 severity of the symptoms described as being caused by a dose equivalent to only the T3T6^h of the 

 weight of the frog may thus be accounted for. If this view be correct, the dose of Experiment VI. 

 should be about 025 grain, or the tto"o *h of the weight of the frog. 



