CHEMICAL CONSTITUTION AND PHYSIOLOGICAL ACTION. 



719 



in the other, complete loss of function occurred in the spinal cord before it 

 occurred in the motor nerves. 



The following Table contains a short account of these experiments : — 



No. of 

 Experi- 

 ment. 



Weight 



of 



Frog. 



Relation 



of Weight 



of Frog 



to Dose. 



Dose. 



Effect. 



LXXI. 

 LXXII. 

 LXXIII. 

 LXXIV. 



LXXV. 



LXXVI. 



LXXVII. 



LXXVIII. 



LXXIX. 



112 grs. 

 200 grs. 

 256 grs. 

 290 grs. 



110 grs. 

 140 grs. 

 110 grs. 

 110 grs. 

 115 grs. 



TT2 - (r tn. 



T^uth. 

 A* 



i th 



1 th 

 ■STB 1 "- 



i th 

 1 th 



■25-yth. 



01 gr. 

 0-2 gr. 



03 gr. 

 0-36 gr. 



0-2 gr. 

 0-3 gr. 

 0-3 gr. 

 0-3 gr. 



04 gr. 



Complete paralysis of motor nerves in 1 hour. 



,, „ reflex function of spinal cord in 1 ho. 35 min. 



Complete paralysis of motor nerves in 40 minutes. 



„ „ reflex function of spinal cord in 1 ho. 10 min. 



Complete paralysis of motor nerves in 1 hour 25 minutes. 



„ „ reflex function of spinal cord in 1 ho. 25 min. 



Complete paralysis of motor nerves in 18 minutes. 



„ „ reflex function of spinal cord in from 2 to 18 

 hours. 



Complete paralysis of reflex function of spinal cord in 47 minutes. 

 „ ,, motor nerves in from 1 ho. 20 min. to 22 ho. 



Complete paralysis of reflex function of spinal cord in 35 minutes. 

 ,, ,, motor nerves in from 1 ho. 20 min. to 21 ho. 



Complete paralysis of motor nerves in 30 minutes. 



,, ,, reflex function of spinal cord in 1 ho. 30 min. 



Complete paralysis of reflex function of spinal cord in 49 minutes. 

 „ ,, motor nerves in 1 hour 14 minutes. 



Complete paralysis of reflex function of spinal cord in 28 minutes. 

 ,, ,, motor nerves in 35 minutes. 



In the experiments in this Table, in which doses between the ± ^ th and 

 the -g^th of the frog's weight were given, the complete paralysis of the motor 

 nerves occurred before the complete paralysis of the reflex function of the spinal 

 cord ; and in the experiments in which doses between the 5-ihyth and the -g-g-yth 

 were given (excepting Experiment LXXVII.), the complete paralysis of the mStor 

 nerves occurred after that of the reflex function of the spinal cord. As we have 

 already said, these two actions are, however, of nearly equal energy; for, at the 

 time when the one has been completed, the other is usually nearly so. Experi- 

 ment LXXVII., in wdiich a dose equivalent to the VJ^h was administered, con- 

 spicuously illustrates this nearly simultaneous progress, by its occurrence as an 

 exception to the order in which the two actions are usually completed after such 

 a dose. 



We have accordingly shown that Mr Moeson's conia differs from that of 

 Dr Christison, both in lethal activity and in mode of action. We shall en- 

 deavour to explain these differences in a subsequent portion of this paper ; the 

 explanation of the varieties in the mechanism of the paralysing action of Mr 

 Morson's conia being dependent on results obtained by our experiments with 

 methyl- conia. 



Hydrochlorate of methyl-conia (C 8 H 14 (CH 3 )NHC1). — Iodide of methyl acts 

 readily upon conia, producing a syrupy or crystalline substance, which is a mixture 



