728 DBS CRUM BROWN AND FRASER ON THE CONNECTION BETWEEN 



No. of 

 Experi- 

 ment. 



Substance 

 Employed. 



Animal and its 

 Weight. 



Dose, by 



subcutaneous 



injection. 



Eelation 

 of Dose to 

 Weight of 



Animal. 



Effect. 



LIII. 



LIV. 

 LXVI. 



LXVIII. 

 LXXX. 



LXXXI. 

 XCVII. 



XCVIII. 



Hydrochlorate of 

 Dr Chkistison's 

 conia. 



Do. 



Hydrochlorate of 

 Mr Mokson's 

 conia. 



Do. 



Hydrochlorate of 

 methyl-conia. 



Do. 



Iodide of dimethyl- 

 conium. 



Do. 



Rabbit, 3 lbs. 

 14J oz. 



Do., 3 lbs. 6J oz. 

 Do., 2 lbs. 12 oz. 



Do., 4 lbs. 1 oz. 

 Do.,31bs.l4ioz. 



Do., 2 lbs. 10^ oz. 

 Do., 3 lbs. 6£ oz. 



Do., 4 lbs. 



0-1 gr. 



0-2 gr. 

 0-2 gr. 



1 gr. 

 0-1 gr. 



0-2 gr. 

 2*5 grs. 



3grs. 



TT8TTT7 1,11 ' 



■Btfsstri'h. 

 I th 



l th 



] th 



1 til 

 1 d 



Slight degree of stiffness in the 

 limbs, followed by recovery. 



Death, in 32 minutes. 

 None. 



Death, in 33 minutes. 

 None. 



Death, in 22 minutes. 



Slight paralysis, followed by re- 

 covery. 



Death, in 1 hour and 15 minutes. 



[This investigation into the physiological action of atropia and its methyl and 

 ethyl derivatives, and of conia and its methyl derivatives, was commenced in 

 July 1867; but, after performing a number of experiments, we considered it 

 advisable to postpone the further examination of these substances until we had 

 finished that portion of our researches which is published in Vol. XXV. Part 1 of 

 the " Transactions." Although an abstract was read before the Society on the 18th 

 of January 1869, this paper was not delivered to the Secretary for publication 

 until the month of October.] 



The subjoined Tabular Summary contains the leadiDg facts of all the Experi- 

 ments included in the present part of this investigation. 



