THE ACTIONS OF PHYSOSTIGMA AND ATROPIA. 



541 



Number 

 of Experi- 

 ment. 



Weight of 

 Rabbit. 



Actual Dose. 



Dose per 



3 lbs. Weight 



of Animal. 



Result. 



Notes. 



6 



2 lbs. 15 oz. 



7'34 grs. 



7 '5 grs. 



Recovery. 



Do. ; excepting reduction 

 in the frequency of the 

 respirations. 



7. 



2 lbs. 4 oz. 



6 grs. 



8 grs. 



Recovery. 



Do. do. ; and production 

 of hypnosis. 



8. 



3 lbs. 



9 grs. 



9 grs. 



Recovery. 



Dilatation of the pupils, 

 increase in the frequency 

 of the cardiac and respira- 

 tory movements, and 

 slight paralysis were pro- 

 duced. 



9. 



3 lbs. 2 oz. 



15 '6 grs. 



15 grs. 



Recovery. 



Dilatation of the pupils, 

 acceleration of the heart's 

 action, increase followed 

 by reduction in the rate 

 of the respirations, dis- 

 tinct paralysis, and tre- 

 mors and starts, were 

 produced. 



10. 



2 lbs. 12 oz. 



16 '5 grs. 



18 grs. 



Recovery. 



Do. 



11. 



3 lbs. 



19 '5 grs. 



19 "5 grs. 



Recovery. 



The chief effects were 

 dilatation (not extreme) 

 of the pupils, acceleration 

 followed by slowing and 

 weakening of the heart's 

 action ; reduction in the 

 rate of the respirations ; 

 hypnosis ; and well- 

 marked paralysis. 



12. 



2 lbs. 13 oz. 



19-9 grs. 



21 grs. 



Death, in more 

 than 1 hour, and 

 less than 5 hours 

 30 minutes. 



Do. 



13. 



2 lbs. 13J oz. 



19-9 grs. 



21 grs. 



Recovery. 



Do. 



14. 



3 lbs. 2 oz. 



23-43 grs. 



22-5 grs. 



Recovery. 



Do. 



15. 



3 lbs. 1| oz. 



22-9 grs. 



22-5 grs. 



Recovery. 



Do. 



16. 



3 lbs. 6 oz. 



27 grs. 



24 grs. 



Death in 35 

 minutes. 



The chief effects were 

 dilatation (not extreme) 

 of the pupils ; accelera- 

 tion soon followed by 

 slowing and great weak- 

 ening of the heart's 

 action ; reduction in the 

 rate and strength of the 

 respirations ; paralysis ; 

 and feeble tremors and 

 spasms. 



In each of these experiments every precaution was taken to prevent fallacy 

 It will, however, be observed, that while, in one case, a dose of 21 grains, and 

 in another one of 24 grains per three pounds weight, was found sufficient to cause 



VOL. XXVI. PART III. 7 B 



