554 DR THOMAS R. FRASER ON THE ANTAGONISM BETWEEN 



being perfectly well, and weighing three pounds and twelve ounces and a 

 half. 



Experiment 44-b.— I injected one grain and a half of extract of physo- 

 stigma, suspended in 15 minims of distilled water, under the skin at the 

 right flank, and immediately afterwards washed out the syringe and injected 

 the washings under the skin at the right hip. Effects were produced in every 

 essential character analogous to those that have been described as occur- 

 ring in the preceding experiments with the extract, and in fifteen minutes 

 the animal was lying on the abdomen and chest. At this time the only 

 noteworthy symptoms were an unusually abundant escape of saliva from the 

 mouth, and a remarkable frequency in the voiding of pultaceous faeces. In 

 twenty-three minutes the rabbit fell over on the side, and while it remained 

 in this position the respirations were laboured and greatly obstructed by 

 mucus accumulated in the larynx and air passages, the pupils were con- 

 tracted, and the cardiac impulses of infrequent occurrence. In twenty-five 

 minutes a marked improvement occurred in the general condition of the rab- 

 bit ; it turned so as to rest on the abdomen and chest, the head was frequently 

 raised, and the respirations became more frequent and almost free from 

 obstruction. This improvement was, however, of but short duration, for in 

 forty minutes the respirations again became embarrassed, tremors and irregular 

 and somewhat energetic general movements occurred, and the rabbit again 

 fell over on the side. Gradually the respiratory movements became less 

 frequent, frothy saliva escaped from the mouth and accumulated in the larynx, 

 the pupils diminished in size, and the heart's impulses became feeble and in- 

 frequent. Soon afterwards the respirations assumed the character of laboured 

 gasps, greatly impeded by an abundant accumulation of frothy mucus, and they 

 finally ceased at fifty-four minutes after the injection of the extract. 



Experiment 45-a. — In a young rabbit weighing two pounds and eight 

 ounces, I injected half a grain of sulphate of atropia, dissolved in 15 minims 

 of distilled water, under the skin at the right flank, and then one grain of ex- 

 tract of physostigma, suspended in 15 minims of water, under the skin at the 

 left flank. Immediately afterwards the water used in washing out each of the 

 syringes was injected under separate parts of the skin. 



Before the experiment the pupils measured ^fths x ^tyths °f an inch, and 

 in two minutes after the commencement of the first injection they had enlarged 

 to ^-§ths x ^f ths of an inch, while slight fibrillary twitches were observed at 

 the right side in the immediate neighbourhood of the regions where physo- 

 stigma had been injected. In seven minutes the rabbit became restless ; in 

 thirteen minutes the pupils had still further enlarged to T^ths x ^§ths of an 

 inch ; and in fourteen minutes several fsecal pellets were passed, and the 

 fibrillary twitches were more marked, and occurred over the whole surface of 





