562 



DR THOMAS R. FRASER ON THE ANTAGONISM BETWEEN 





Cardiac 



Respirations, 



Size of Pupils, in 







Contractions, 



per 



fractions of an 



General Symptoms, &c. 





per 10 seconds. 



10 seconds. 



inch. 





In 9 min. 30 sec. 



61 



19 



J£ths x Hths 



Saliva has ceased to flow from the 

 mouth. 



11 „ 30 „ 









Has succeeded in turning from side, 

 and is now lying on the abdomen 

 and chest, with the lower jaw rest- 

 ing on the table. 



20 „ 





20 





Moist sounds occasionally accompany 

 the respirations. Efforts are made 

 to arch the back. Fibrillary twitches 

 have become so frequent that it is 

 impossible to count the cardiac im- 

 jjulses, but tbey are ascertained to 

 be very frequent. 



25 „ 





21 



Htlis x Jfths 



The back is now arched, but the lower 

 jaw stdl rests on the table, and the 

 anterior extremities are extended 

 flaccidly at right angles to the body. 



30 „ 30 „ 



61 



16 



— 



Tbe fibrillary twitches are less marked. 



36 „ 







fj-ths x £$ths 



The rabbit got up and walked a short 

 distance slowly and unsteadily. The 

 transverse diameter of tbe pupils is 

 greater than the perpendicular. 



60 „ 



50 



19 



$£ths x if ths 



Now and then the rabbit goes about 

 with great difficulty, but usually 

 rests quietly on the abdomen and 

 chest. At rare intervals moist 

 sounds accompany the respirations. 



120 „ 









There is only a little difficulty present 

 when the rabbit goes about. It 

 usually sits normally, with slight 

 drooping of the head. The fibrillary 

 twitches are prominently marked. 



160 „ 



42 



11 



M ths x Hths 



The general condition remains as last 

 noted, except that the fibrillary 

 twitches are now only slightly 

 marked. Neither defalcation nor 

 urination have occurred since the 

 injection of the atropia. 



On the following day — twenty-three hours after the commencement of the 

 experiment — the rabbit was lively and well. It was ascertained that the cardiac 

 impulses occurred at the rate of 28, and the respiratory movements at that of 

 9, in ten seconds. The pupils measured ^-ths x ^§ths of an inch. 



On the fourth day, the restoration of every affected function to a normal 

 state appeared to have been perfected ; for now the cardiac contractions and 

 the respiratory movements had returned to their usual rate of 39 and 22 in ten 

 seconds, while the pupils measured i^yths x ^%ihs of an inch, which exactly cor- 

 responded to their measurement before this experiment was made. 



Experiment 50-b. — On the tenth day this rabbit received, by subcutaneous 

 injection, nine-fiftieths of a grain of sulphate of physostigmia. It had previously 



