576 DR THOMAS R. FRASER ON THE ANTAGONISM BETWEEN 



2. The influence that is exerted by atropia upon the lethal action of extract 

 of physostigma and sulphate of physostigmia has been examined in rabbits, and 

 a description has been given of several experiments that were performed for 

 this purpose. The following facts have been stated among the conditions and 

 results of these experiments : — 



Experiment 41-a. — A rabbit, weighing 2 lbs. 15^ oz., received 3 grain of 



sulphate of atropia ; and, five minutes afterwards, 1 -2 

 grain of extract of physostigma. Recovery took place. 

 41-b. — Ten days afterwards, the same rabbit, now weighing 3 lbs., 

 received 1*2 grain of extract of physostigma. Death 

 occurred in twenty-two minutes. 



Experiment 42-a. — A rabbit, weighing 3 lbs. 4 oz., received 017 grain of sul- 

 phate of atropia; and, five minutes afterwards, 3 9 grains 

 of extract of physostigma. Recovery took place. 

 42~b. — Eight days afterwards, the same rabbit, now weighing 3 lbs. 

 5 oz., received 1*3 grain of extract of physostigma. Death 

 occurred in thirty-one minutes. 



Experiment 43-a. — A rabbit, weighing 3 lbs., received 0*5 grain of sulphate of 

 atropia; and, five minutes afterwards, 0*24 grain of sul- 

 phate of physostigmia. Recovery took place. 

 43b. — Nine days afterwards, the same rabbit, now weighing 3 lbs. 

 4 oz., received 0*24 grain of sulphate of physostigmia. 

 Death occurred in nine minutes and fifty seconds. 



Experiment 44-b. — A rabbit, weighing 3 lbs. 12 oz., received 0*5 grain of sul- 

 phate of atropia ; and, nearly at the same time, 3 grains 

 of extract of physostigma. Recovery took place. 

 44-b. — Nine days afterwards, the same rabbit, now weighing 3 lbs. 

 12J oz., received 1*5 grain of extract of physostigma. 

 Death occurred in fifty-four minutes. 



Experiment 45-a. — A rabbit, weighing 2 lbs. 8 oz., received 0*5 grain of sul- 

 phate of atropia ; and, nearly at the same time, 1 grain of 

 extract of physostigma. Recovery took place. 

 45~b. — Thirteen days afterwards, the same rabbit, now weighing 

 2 lbs. 9 oz., received 1 grain of extract of physostigma, 

 Death occurred in eighteen minutes. 



Experiment 46-a — A rabbit, weighing 3 lbs. 2 oz., received 25 grains of 



extract of physostigma ; and, five minutes afterwards, 5 

 grain of sulphate of atropia. Recovery took place. 

 46- b. — Eleven days afterwards, the same rabbit, now weighing 3 lbs. 

 2f oz., received 2*5 grains of extract of physostigma. 

 Death occurred in eleven minutes and thirty seconds. 



