582 



DE THOMAS R. FRASER ON THE ANTAGONISM BETWEEN 



per three pounds weight of rabbit will alone be mentioned. For further details, 

 and more especially for the actual doses, the weight of the animals, and the 

 chief symptoms, I must refer to the Tabular Summary at the end of the 

 paper. 



1. Determination of the Limits of Antagonism when Atropia is 

 administered flve mlnutes before physostigma. 



In this series of experiments, physostigma was administered in the form of 

 extract. It has already been shown that the minimum lethal dose of this 

 preparation is 1"2 grain per three pounds weight of rabbit. 



Experiments with the Minimum-Lethal Dose of Physostigma. — In accordance 

 with the plan which has been indicated, the first experiments of the series were 

 made to determine what doses of atropia can prevent the fatal action of the 

 minimum-lethal dose of physostigma. In the experiments performed for this 

 purpose,* the following results were obtained :— 





Experiment 71.t — With 0-005 grain of sulphate 



Experiment 72-a. 

 Experiment 73-a. 

 Experiment 74-a. 

 Experiment 75-a. 

 Experiment 76~a. 

 Experiment 77 -a. 

 Experiment 41-a.} 

 Experiment 78-a. 

 Experiment 79-a. 

 Experiment 80-a. 

 Experiment 81-a. 

 Experiment 82-a. 

 Experiment 83-a, 

 Experiment 84. 

 Experiment 85. 

 Experiment 86. 

 Experiment 87. 



0009 



0015 



0-02 



0-025 



0031 



0-05 



0-3 



0-92 



o. 



3- 



4-3 



5' 



5-2 



5-3 



5-3 



5-4 



5-5 



srams 



of atropia, death occurred, 

 recovery 

 recovery 

 recovery 

 recovery 

 recovery 

 recovery 

 recovery 

 recovery 

 recovery 

 recovery 

 recovery 

 recovery 

 recovery 

 death 

 death 

 death 

 death 



* Tabular Summary, Series 1, Tattle 2. 



+ Except in two cases, the numbers of these experiments have reference to the arrangement that 

 has been followed in the Tabular Summary at the end of the paper, where the leading facts connected 

 with'all the experiments belonging to this Section ofthe research are mentioned. 



X A full description of the experiment has already been given in Section A. (see p 544). 



