THE ACTIONS OF PHYSOSTIGMA AND ATROPIA 



585 



Experiment 118.— With 0-011 grain of sulphate of atropia, death occurred. 



Experiment 119. 

 Experiment 120. 

 Experiment 121-a. 

 Experiment 122-a. 

 Experiment 123-a. 

 Experiment 124-a. 

 Experiment 125-a. 

 Experiment 126-a. 

 Experiment 127- a. 

 Experiment 128-a. 

 Experiment 129-a. 

 Experiment 130-a. 

 Experiment 131-a. 

 Experiment 132-a. 

 Experiment 133-a. 

 Experiment 134-a. 

 Experiment 135. 

 Experiment 136-a. 

 Experiment 137. 

 Experiment 138. 

 Experiment 139. 



The smallest dose of sulphate of atropia that can prevent the occurrence of 

 death after the administration of two and a half times the minimum-lethal dose 

 of physostigma is thus seen to be about one-fortieth of a grain ; and it is 

 remarkable that this is also the smallest dose that can prevent the occurrence 

 of death after twice the minimum-lethal dose of physostigma. The experiments 

 likewise show that doses of sulphate of atropia ranging from one-fortieth of a 

 grain to two grains and a fifth are able to prevent the fatal action of two and 

 a half times the minimum-lethal dose of physostigma ; and that death occurs 

 if the dose of atropia amount to two grains and three-tenths. In Experiment 

 135, death occurred with two grains of sulphate of atropia : but I am inclined 

 to look upon this result as exceptional ; for in the previous experiment the 

 same dose was followed by recovery, and in the subsequent experiment the 

 larger dose of two grains and a fifth was likewise followed by recovery. Death 

 was probably due to some accidental peculiarity in the condition of the rabbit, 

 by which the general vigour was depreciated. 



Experiments ivith Three times the Minimum- Lethal Dose of Physostigma. — 

 When atropia was administered five minutes before a dose of physostigma 

 vol. xxvi. part hi. 7 N 



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