586 



DR. THOMAS R. FRASER ON THE ANGTAGONISM BETWEEN 



Experiment 141. 



>> 



0-05 



Experiment 142-a. 



>> 



006 



Experiment 143a. 



>> 



0076 



Experiment 144-a. 



»5 



0-088 



Experiment 42-a. t 



>> 



016 



Experiment 145-a. 



JJ 



5 



Experiment 146-a. 



>> 



1- 



Experiment 147-a. 



>> 



1-2 



Experiment 148. 



!) 



1-3 



Experiment 149. 



>> 



1-4 



Experiment 150. 



)> 



1-9 



three times as large as the minimum-lethal, the following results were 

 obtained : — * 



Experiment 140. — With 0*043 grain of sulphate of atropia, death occurred. 



„ death 



„ recovery 



„ recovery 



„ recovery 



„ recovery 



„ recovery 



„ recovery 



„ recovery 



„ death 



„ death 



„ death 



These experiments show that while one-twentieth of a grain of sulphate of 

 atropia is insufficient to prevent the occurrence of death after the administra- 

 tion of three times the minimum-lethal dose of physostigma, three-fiftieths of a 

 grain is sufficient to do so. They likewise show that the lethal action of this 

 dose of physostigma may be prevented by any dose of sulphate of atropia 

 from three-fiftieths of a grain to one grain and a fifth ; but that if the latter 

 dose be exceeded, the region of successful antagonism is left and death occurs. 



Experiments with Three and a half times the Minimum- Lethal Dose of Physo- 

 stigma. — When the dose of physostigma was three and a half times the minimum 

 lethal, the following results were obtained : — \ 



Experiment 151. — With 0-044 grain of sulphate of atropia, death occurred. 



Experiment 152. „ 0-071 „ „ death 



„ recovery 



„ recovery 



„ death 



„ death 



„ death 



Accordingly, when the dose of physostigma is so large as three and a half 

 times the minimum-lethal, the range of doses of atropia that can prevent death 

 is a very limited one, extending only from one-tenth to one-fifth of a grain. 



* Tabular Summary, Series 1, Table 6. 



t A full description of this experiment has already been given in Section A. (see p. 546). 



\ Tabular Summary, Series 1, Table 7. 



§ Five days after this experiment, the rabbit became weak and languid ; from that time it 

 gradually lost weight and condition ; and on the twentieth day, it died. The usual experiment with 

 a dose of physostigma alone could not, therefore, be made. 



Experiment 153. § 



„ 01 



Experiment 154- a. 



„ 0-2 



Experiment 155. 



„ 0-3 



Experiment 156. 



„ 0-5 



Experiment 157. 



n I" 



