592 



DR THOMAS R. FRASER ON THE ANTAGONISM BETWEEN 



Experiment 174-a. — With 0*5 grain of sulphate of atropia recovery occurred. 



recovery 

 recovery 

 recovery 

 recovery 

 death 

 death 

 death 

 death 

 death 

 death 



Experiment 175-a. 



>> 



1- 



Experiment 176-a. 



;> 



2" grains 



Experiment 177-a. 



11 



2-4 



Experiment 178-a. 



n 



25 



Experiment 179. 



11 



2-6 



Experiment 180. 



11 



2-7 



Experiment 181. 



n 



2-8 



Experiment 182. 



11 



3- 



Experiment 183. 



n 



32 



Experiment 184. 



>> 



4- 



Accordingly, if sulphate of atropia be administered five minutes after the 

 minimum-lethal dose of physostigma, death occurs when the dose of sulphate 

 of atropia is not more than three two-hundredths of a grain, recovery when 

 the dose is from one fiftieth of a grain to two grains and a half, and death again 

 when the dose is larger than two grains and a half. The range of the doses of 

 atropia that can prevent the lethal effect of this quantity of physostigma is, 

 therefore, considerably less when physostigma is administered five minutes 

 before atropia, than when it is administered five minutes after it; and it will 

 be observed that there is a like difference between the results in all the other 

 corresponding groups of experiments in the two series. 



Experiments with One and a half times the Minimum-Lethal Dose of Physo- 

 stigma. — In the next instance, the limits of successful antagonism were deter- 

 mined in the case of a dose of physostigma one and a half times as large as the 

 minimum-lethal : — •* 



Experiment 185. — With 03 grain of sulphate of atropia, death occurred. 



Experiment 186-a. , 



, 0-05 



» 



11 



recovery , 



Experiment 187-a. , 



, 01 



n 



11 



recovery , 



Experiment 188-a. , 



, 0-2 



>> 



11 



recovery , 



Experiment 189-a. , 



, 03 



11 



11 



recovery , 



Experiment 190-a. , 



, 04 



11 



11 



recovery , 



Experiment 191-a. , 



, 0-5 



11 



11 



recovery , 



Experiment 192-a. , 



, 07 



11 



11 



recovery , 



Experiment 193-a. , 



, 12 



11 



11 



recovery , 



Experiment 194 -a. , 



, 1-5 



11 



11 



recovery , 



Experiment 195-a. , 



, 2 grains 



11 



11 



recovery , 



Experiment 196- a. , 



, 21 



11 



11 



recovery , 



* Tabular Summary, Series ii. Table 3. 



