594 DE THOMAS R. FRASER. ON THE ANTAGONISM BETWEEN 



These experiments prove that when sulphate of atropia is administered five 

 minutes subsequently to a dose of physostigma twice as large as the minimum- 

 lethal, nine one-hundredths of a grain of the former substance is too small a 

 dose to prevent death ; that doses ranging from one-tenth of a grain to one 

 grain and a fifth are sufficient to do so ; and that if the dose be larger than one 

 grain and a fifth, the higher limit of success is passed, and death occurs. 



Experiments ivith Two and a half times the Minimum- Lethal Dose of Physo- 

 stigma. — The experiments of the next group were made with a dose of physo- 

 stigma two and a half times as large as the minimum-lethal.""" The doses of 

 sulphate of atropia that were given with this dose of physostigma, and the 

 results of the experiments are as follows : — 



Experiment 224. — With 05 grain of sulphate of atropia, death occurred. 



Experiment 225. ,, 0-08 „ „ death 



Experiment 226-a. „ 1 „ „ recovery 



Experiment 227-a. „ 015 „ „ recovery 



Experiment 228-a. „ 0"2 „ „ recovery 



Experiment 229-a. „ 3 „ „ recovery 



Experiment 230-a. „ 0"5 „ „ recovery 



Experiment 231-a. „ 0*6 „ „ recovery 



Experiment 232-a. „ 0*7 „ „ recovery 



Experiment 233 a. „ 0-8 „ „ recovery 



Experiment 234. „0.8 „ „ death 



Experiment 23s. „ 0*9 „ „ death 



Experiment 236. „ 1" „ „ death 



Experiment 237. „ 1-5 „ „ death 



Accordingly, when two and a half times the minimum-lethal dose of physo 

 stigma was given five minutes before sulphate of atropia, the range of doses of 

 the latter substance, capable of producing successful counteraction, extended 

 only from one tenth to about seven tenths of a grain. 



Experiments with Three times the Minimum-Lethal Dose of Physostigma. — 

 When the dose of physostigma was three times as large as the minimum- 

 lethal, t the following results were obtained : — 



Experiment 238. — With 01 grain of sulphate of atropia, death occurred. 

 Experiment 239. „ 015 „ „ death 



Experiment 240-a. „ 016 „ „ recovery „ 



Experiment 241. „ 0*2 „ „ death 



Experiment 242. „ 0*25 „ „ death 



* Tabular Summary, Series ii. Table 5. f Ibid., Table 6. 



