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WiYA atropia, none. 



-4/fcr physostigma, in 8 min., 

 slight paralysis; and in 15 

 min., general ftaccidity, which 

 increased until death. Tre- 

 mors and feeble convulsive 

 spasms frequently occurred ; 

 and fibrillary twitches were 

 present in a very well-marked 

 form until 17 min. after the 

 administration of physostigma. 

 Rigor had not set in at 1 hour 

 after death. 



a 



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 c 



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With atropia, none. 



After physostigma, neither de- 

 fajcation nor urination occur- 

 red ; but the secretion of 

 certain buccal or bronchial 

 glands was shown to be in- 

 creased by moist sounds occa- 

 sionally accompanying the 

 respirations. 



Effect on the Respirations. 



With atropia, none 

 noted. 



After physostigma, the 

 rate per 10 sec. was in 

 14 min., 18; in 19 min., 

 12 ; and in 20 min., 2. 

 Afterwards, feeble gasps 

 occurred at irregular in- 

 tervals until death. 



s 



O 

 CO 



With atropia, in 4 min. , 

 acceleration from 39 to 

 52 per 10 sec. 

 After physostigma, in 

 4 min., the rate per 10 

 sec. was 53. Twitches 

 and tremors prevented 

 any exact observations 

 being subsequently 

 made ; but in 22 min., 

 the impulse was rapid. 



Effect on the Pupils. 



(The Measurements are in 



fiftieths of an inch.) 



With atropia, in 3 min., 

 dilatation from if x i-jj 



tol 6 y 1 6 

 "BIS" * "5TJ"- 

 After physostigma, fur- 

 ther dilatation soon 

 took place to -j-J x -^f ; 

 and this size was main- 

 tained until death. — 

 After death, in 5 min., 

 the size was %% x |f-. 



1 

 co 



Death, in 

 29 min. 

 after the 

 administra- 

 tion of phy- 

 sostigma. 



Dose of 

 Physostig- 

 ma (in 

 Grains). 

 Actual 

 Dose of 

 Extract. 



"P 



03 



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 h so 

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 short 

 n., d 

 •2 mil 

 uentl 

 mo 

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 laboi 





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With a 



After p 

 30 sec., 

 fibrillar 

 became 

 again 1 

 before c 

 tinct pa 

 general 

 tremors 

 rarely, 

 After d 

 ance of 

 hour 20 

 torv 59 













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 o 



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 S ' 



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 -UO 



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 certain bi 

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 s ceased i 

 n 20 min 

 . pellets v 

 v&s no sah 

 n. 





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 o 



atropia, in 3 min 

 ration from 23 t 

 r 10 sec. 



physostigma, th 

 ler 10 sec. was, i 

 ., 22; in 20 min. 

 i 24 min., 5; an 

 min., 4. Aftei 

 , only very feebl 

 rregularly occui 

 respirations too 

 until death. 





o 







With 

 aecele 

 26 pe 

 After 

 rate t 

 4 min 

 18; i 

 in 24 

 wards 

 and ] 

 ring 

 place 







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 o 



itropia, 

 •ation f 

 10 sec. 

 physost 

 er 10 se 

 , 52; ii 

 7 min., 

 28; a 

 30. 





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With 

 aecele 

 52 pel 

 After 

 rate p 

 2 min 

 45; in 

 min., 

 min., 





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