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IN MAN AND OTHER MAMMATIA., 365 
This formation of young Graafian follicles takes place in the egg clusters in 
all parts of the ovary, and at the same time new egg clusters are being formed 
under the germ epithelium in the manner described. In the ovary of a 74 
months’ human foetus we find many newly-formed egg clusters immediately 
under the germ epithelium, but below these, earlier formed egg clusters are in 
various stages of alteration into single egg-containing follicles, while deeper 
still we find a great number of young follicles all produced from the first formed 
clusters in the way we have described (fig. 24). 
In the first formed Graafian follicles, which are situated most deeply in the 
stroma of the ovary, the young ova are of large size, and we are at once struck 
by the fact that the germinal vesicles in all are about the same size, although 
the protoplasm around them may vary considerably in quantity. 
In each young Graafian follicle the ovum fits tightly; it occupies the whole 
cavity of the follicle; there is no space between it and the wall (fig. 24, m, m, m). 
The mesh of stroma closely embraces the protoplasm of the ovum, and in almost 
every case we find fusiform connective tissue corpuscles (”, m) in the wall of 
the mesh lying in close contact with and indenting the yelk of the young ovum. 
Wherever we examine the primordial follicles, we see such fusiform corpuscles 
of the stroma lying in contact with and indenting the yelk of the contained ova. 
I called attention to the circumstance that among the germ epithelial corpuscles 
on the surface of the ovary primordial ova were found, having in contact with 
their protoplasm small fusiform corpuscles, which in some instances could be 
traced growing as offshoots from delicate bundles of similar bodies which 
formed part of the ovarian stroma. 
(e.) The Development of the Membrana Granulosa.—The stroma of the human 
foetal ovary is remarkable for the great number of connective tissue corpuscles 
it contains. Wherever we examine the stroma and its processes in all parts 
of the ovary, we find in it well-formed connective tissue corpuscles. In the 
middle parts of the ovary, where the stroma is well developed, the connective 
tissue corpuscles show very distinctly a central oval nucleus with nucleolus. 
Around the nucleus is a small quantity of protoplasm, drawn out at either end 
in a fusiform manner. Besides these we see naked nuclei and many small 
round bodies; in these latter the nucleus is in a state of division into two or 
more parts. These small round bodies appear to be swollen out connective 
tissue corpuscles. In a well-formed connective tissue corpuscle the nucleus 
is comparable to the germinal vesicle of the ovum, and like it, at a certain 
stage of its development, it shows a sharply-defined double contoured wall. 
In all parts of the ovary we find the connective tissue corpuscles dividing. 
In various parts of the stroma we find delicate fibres developing into 
connective tissue corpuscles. The central part of such fibres becomes swollen 
out, and in this swollen out part a distinct oval nucleus appears; sometimes 
VOL. XXVII. PART III. oC 
