33 
used alone, and the alkaloids would be at once obtained in a much 
greater state of purity. I soon satisfied myself that the employment of 
a mixed solvent of this description would have many advantages over 
chemist. Under these d a Aa was not in a posit o make 
any further suggestions regarding the process of A ote at ‘Sikkim, 
and I therefore let the matter drop. 
* Later on, however, I heard that Mr. Gammie, who still conducted 
the EGRE HC: of febrifuge e, was also attempting the it of 
pure quinine sulphate from the calisaya bark ; and a dence 
began between Mr. Gammie and myself on this ‘subject, p about this 
time Dr. King came on a visit to Europe, and in the autumn of 1884 
I bad an opportunity of inane. with him the practicability of the 
sore Mr. Gammie was making at Mungpoo. At that time à ca 
pr : 
The alkaloid was completely extracted from the dua but it was 
mewhat too complicated for use on the plantations. Dr. King, during 
d. stay in Holland, had acquired some valuable nagar: regarding 
the paraffine oil process as used in the Continental oil fac ‘tories, and he 
consulted me regarding it. I was impressed with certain difficulties, 
which I thought would attend its employment by Mr, Gammie, aud I 
did not feel that I could then assist him much in that direction, It 
seemed to me, however, a favourable moment to make a further trial of 
the modification of the fusel oil process to which I have already referred, 
namely, the employment of fasel oil diluted with some liquid hydrocarbon 
for the extraction of the bark. Accordingly, I resumed my experiments 
on the use of such a mixed solvent, and worked out two or three 
alternative processes. These d differed: from each other chiefly in the 
nature of the diluting hydrocarbon. In one, the mixed solvent was 
formed ux aukag the fusel with odi ^ six times its volume of the 
a new Pharmacopoia, as likely to furnish the basis of a convenient 
analytical fathead Mor yen die the alkaloidal value of the cinchona 
used in medicine, and the process is now the official test for that 
e in the present British Pharmacopeia, The use of a n 
naphtha, whether derived from coal, shale, or petroleum, for iluting 
oil was therefore diluted with ordinary kerosine. As this oil is so 
largely used for illuminating purposes in India, and is p : 
readily obtainable there, this method offered the greatest ta 
1 
ne Whee m Met Gammie visited England in the summer of 1885, he came 
to my toria and witnessed the experimental working of this process; 
and formed a favourable opinion of its adaptability for use on t 
planeitions: On his return to Mungpoo, he began a trial of k oM 
in extracting gan bark, and the satisfactory results Miser T 
encouraged him to go on. With great perseverance he aa P EN 
detail after jit using M the Ws bitte as apie that Ms ale. 
hand, until he was able to e miba s Piel ini Ap 
The valuable Febültó nien which have ive bel thus far a 
