33. 

 Figure 33 shows graphically tie average dnily C0 2 production, the 

 par cant of nonr.al CO,, production, the tot'il amount regenerated as per cant of 

 tho amount removed, and the tiaw required to regenerate 7.5jt of the amount re- 

 moved, while theee cxrvea aro in no wise cot3p'.«rable, they asnre to fcrin? out 

 more clearly tha progressive reduction in rate an! amount of raganeratlon and in 

 carbon dioxide pro 1 -action dua to increasing acidity of tha medium. 



Halation of Site to Carbon Dioxide Pr-.-i ■action an.) Regeneration . 



It haa already been mentions! in connection with experiments one 

 and two tnmt thara la a dlffaranca between large nnll tadpoles in tha 



relation of retardation of regeneration »r»d length of life in various eonoentra- 

 tiona of baaea. Drayar and Walker (1914) show that in warm-blooded animals of the 

 aaite species, but cf dlffarent weights, dosage of drugs oust be Calculated in 

 relation to body surface. they explain this on the ground th<*t *the concentra- 

 tion in Imt plasma of any given substance administered la dependent on the 

 volume of tha circulating blood, which ia Itself proportion-vl to the body surface 

 in any given species of animal." Tha •basal boat production - of a wara-blooded 

 animal, which may be defined a« the heat proiuoel by the animal under consider- 

 ation when kept at tha same temperature aa ito normal body temperature at rest 

 and starving, ia alao regarded as proportional to body surface for any given 



a pec lea. 



A faw axporimente were undertaken to see whether any relationship 



could be traced between the body are* or bodr weight of tadpoles ar.d the effects 

 of acids and bases upon regeneration pjai carbon dioxide production, which may 

 ba regarded '«s moat nearly representing the basal metabolism of tfef la. 



Tor the firat experiment two tadpoles were taken which had been 

 oolleot»« at the eane tl«*,and iif fared enly in weight, git at care being taken 

 that they should be similar in ah^pa, relative langth of tail, sit. After 

 one week of starvation in distill*! trrtar/they were welshed aed the CO- 



