Figures 7 and 8.—Blood smear of control fish (a) and fish exposed to 48 ppm cadmium for 96 hr (b). Note poikilocytosis, karyolkasis, 
and abundant smudge cells in 7b, 8b. 185 (7), 750X (8); Wright’s stain. 
lethal exposure to the metal so that destruction of the 
mucus cells was not an important factor in prognosis. 
Blood 
An understanding of the changes taking place in the 
blood of the cunner must await further study. The in- 
crease in eosinophils noted by Gardner and Yevich 
(1970) was not seen, possibly because of the longer ex- 
posures used in this study. Wilson et al. (1941) noted 
an increase of eosinophils of rats after dietary ex- 
posure to cadmium, and Friberg (1950) found an in- 
crease of eosinophils in rabbit blood from a normal 3% 
level to 25% after exposure to cadmium oxide dust. 
Thrombocytopenia, lymphocytopenia, and 
neutrophilia in the present study parallel the changes 
found by Gardner and Yevich (1970) in mummichogs 
and have also been found in other species under stress 
or after adrenal corticoid administration (Weinreb, 
1958). 
32 
LITERATURE CITED 
AHLMARK, A., B. AXELSSON, L. FRIBERG, and M. PISCATOR. 
1961. Further investigations into kidney function and pro- 
teinuria in chronic cadmium poisoning. Proc. 13th Int. 
Congr. Occup. Health, p. 201-203. 
BILINSKI, E., and R. E. E. JONAS. 
1973. Effects of cadmium and copper on the oxidation of lac- 
tate by rainbow trout (Salmo gairdneri) gills. J. Fish. Res. 
Board Can. 30:1553-1558. 
BURTON, D. T., E. L. MORGAN, and J. CAIRNS, JR. 
1972. Mortality curves of bluegills (Lepomis macrochirus 
Rafinesque) simultaneously exposed to temperature and zi 
stress. Trans. Am. Fish. Soc. 101:435-441. 
CALABRESE, A., R. S. COLLIER, and J. E. MILLER. 
1974. Physiological response of the cunner, Tautogolab 
adspersus, to cadmium. J. Introduction and experimental 
design. Jn Physiological response of the cunner, Tauto- 
golabrus adspersus, to cadmium, p. 1-3. NOAA Tech. Rep. 
NMES SSRF 681 
