1074 



Li, C. P. 1960. 



Antimicrobial activity of certain marine fauna. Proc. Soc. Expt. Biol. Med. 

 104: 366-368. 



Following the discovery that canned abalone juice had an inhibitory effect on 

 experimental poliomyelitis in mice, and that frozen fresh abalone juice 

 inhibited Staphylococcus aureus in vitro, a number of marine animals were 

 tested as possible sources of antimicrobial agents. Abalone juice, oyster 

 juice and extract, and Venus mercenaria extract, demonstrated antimicrobial 

 activity; the others were negative. When a penicillin-sensitive strain of 

 Staphylococcus aureus was used as a test organism, clam extract showed rather 

 consistently a 3 mm inhibiting zone around the absorbent paper disc; oyster 

 extract was negative. By a fluid method of assay, clam extract also showed 

 moderate inhibitory action against a penicillin-resistant strain of S. aureus. 

 The active agent was heat stable and nondialyzable. - J.L.M. 



1075 



Li, C. P. 1972. 



Further research on anticancer agents from the sea. In Food-Drugs from the 

 Sea, Proceedings 1972. Leonard R. Worthen (edj . Mar, Tech. Soc, 

 Washington, D.C.: 396 (abstract) . 



When newborn hamsters were inoculated subcutaneously with adenovirus-12 and 

 treated with clam (presumably Mercenaria mercenaria) extracts 4 or 5 days 

 later, about 50% were protected from developing tumors later in life. Clam 

 extract cannot kill virus in that condition, but could immunize animals 

 against cancer as BCG does. Clam extracts injected directly into tumor in 

 hamsters caused complete regression in 50% of the animals. There may be 

 other components in clam extracts, some of which inhibit, others of which 

 stimulate, immunity. Discovery of tumors in clams makes the problem more 

 complicated. - J.L.M. 



1076 



Li, C. P., W. G. Jahnes,and N. M. Tauraso. 1970. 



Studies on inhibition of viral oncogenesis. II. Inhibitory effect of 

 L-asparaginase, clam liver extract and methotrexate on Rous sarcoma virus 

 focus formation. Arch. Ges. Virusforsch. 32(2-3): 236-243. 



Effect of clam liver extract (CLE) on Rous sarcoma virus (RSV) focus formation 

 was to reduce consistently the number of foci. It was significant when the 

 dose of CLE was more than 10 mcg% and especially when virus multiplicity of 

 the inoculum was high. Methotrexate (MTX) had the strongest inhibitory 

 activity, but when given to hamsters inoculated with adenovirus-12, CLE had 

 an inhibitory effect on tumor formation at least equal to that of MTX. - J.L.M. 



1077 



Li, C. P., B. Prescott, B. E. Eddy, and E. C. Martino. 1968. 



Local chemotherapy of neoplasm in hamsters with clam extract. 9th Internatl. 

 Cancer Congr . , Abstracts of papers: 33. 



Health Sciences Library at Stony Brook has Proc. 9th Internatl. Cancer 

 Congr., but this abstract is not in the volume. No record of publication 

 of abstracts in any form. J.L.M. and M.W.S. 



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