SEA- FISHERIES LABORATORY. 137 



reactions, and its chemical composition snggest that it is allied, 

 or belongs to the amyloid deposits of hnman pathology. 

 The iodine test for amyloid substance was applied successfully, 

 and so far as this goes it indicates that this is part of the nature 

 of the deposit. 



Epitheliomata in the Turbot.— Plate IV, fig. 1. 



A large turbot, which was seized by Mr. T. R. Bailey, 

 Inspector at Fleetwood, was covered with black, raised spots, 

 both on the ocular and blind sides. The fish was very thin 

 and in poor condition, and its eyes were affected by a thickening 

 and opacity of the cornea. The spots on the skin varied in 

 size from about J up to 2 cms. Most of them were, apparently, 

 only black pigment spots, many being hardly raised above the 

 general surface of the skin. Some, however, were raised up 

 about 1 to 2 mm., and were only very slightly pigmented. 

 One of these more prominent lesions was cut out, fixed in 

 Zenker's fluid, and sections were made. One of these sections, 

 stained in methyl-blue-eosin, is represented in fig. 1, PL IV. 



The section includes the integument and part of the 

 underlying systemic muscles : two bundles of the latter are 

 shown. The integument in this fish — a large and full-grown 

 one — consists mainly of a very thick and strong layer of coarse 

 connective tissue fibres. These are arranged in two series, 

 one consisting of bundles of fibres running perpendicularly to 

 the surface of the skin : these are thick and coarse bundles ; 

 and another series consisting of bundles which run parallel 

 to the surface of the skin. These two series of bundles cross 

 each other nearly at right angles ; between them is a loose 

 fibrous tissue with small cells. Between this coarse fibrous 

 layer and the underlying systemic muscles is a loose areolar 

 tissue, and between it and the epidermis is also a rather coarser 

 areolar tissue containing an interrupted layer of black pigment. 

 The epidermis, that is, an evident squamous epithelium lying 



