SEA-FISHERIES LABORATORY. 141 



fixed in Bouin's fluid, and given to me by Mr. Elmhirst, and 

 the figs. 2, 3, and 4 of PI. IV represent the minute anatomy of 

 these structures. 



Fig. 4 represents the appearance of a section through one 

 of these nodules as seen under a low-power lens. It is a nearly 

 globular mass of connective tissue, consisting of wavy bundles, 

 running in all directions. There are numerous, irregularly 

 shaped cavities in the section, and towards the centre of the 

 nodule these are quite empty, but towards the margins many 

 of them contain capillaries or other small blood-vessels. The 

 cavities in the central parts of the nodule were probably also 

 those of blood vessels, and the whole structure appears to be 

 a proliferation of Glisson's capsule. 



Fig. 2 represents a section of a nodule at the margin of 

 the latter. The fibrous structure is sharply delimited from 

 the surrounding liver parenchyma although there is no con- 

 centric capsule, or other limiting layer. Round the periphery 

 of the nodule there is a very rich capillary network, richer than 

 that represented in the figure. Some of these capillary vessels 

 can be traced into the fibrous tissue of the nodule, but most of 

 them appear to be restricted to the immediate neighbourhood 

 of the latter, while still remaining outside it. The fibrosis of 

 the liver is therefore accompanied by an active inflammatory 

 condition. 



Fig. 3 shows the minute anatomy of the liver parenchyma 

 in the immediate vicinity of the fibrous nodules. The ordinary 

 liver cells have disappeared, and in their place is the rich 

 capillary blood vascular network, in the interstices of which 

 are numbers of large round cells loosely and irregularly 

 arranged. These cells have large nuclei with prominent 

 nucleoli. The cell body appears to be richly vacuolated, or to 

 have deposits of some unstainable material. Between them 

 is a debris of apparently broken-down cell material. Nothing 

 in this suggests ordinary hepatic tissue, and it appears to be 



