200 TRANSACTIONS LIVERPOOL BIOLOGICAL SOCIETY. 



In the Mallory preparations most of these obscure bodies 

 stain orange, just as do the nuclei of the red blood 

 corpuscles in other parts of the section where capillaries 

 are present and can be recognised, and in the sections 

 stained with carbol-fuchsin these parts take the stain 

 very intensely. They, therefore, consist mainly of 

 broken-down red blood corpuscles, connective tissue 

 fragments, and masses of bacilli densely aggregated 

 together. 



The remainder of the substance of the lesion between 

 the nodular masses consists of fibrous connective 

 tissue with blood capillaries. It is not richly vascular, 

 but the capillaries with their contents can easily be 

 recognised. It is a granulomatous, or scar, tissue, and 

 doubtless represents the tubercular lesion in process of 

 disintegration and absorption. It contains pigment- 

 melanin granules without much indication of arrange- 

 ment. Here and there this pigment appears in a stellate 

 form, as if it were contained in richly branching cells, 

 but as a rule it is present as small round bodies or 

 discrete granules. 



All the darkly shaded parts in fig. 1, and 

 especially the darkly stippled parts, are the loci of the 

 bacilli staining acid-fast with carbol-fuchsin. The 

 deeply stippled areas represent places where the bacilli 

 are densely clumped. These clumps are spherical masses 

 of various sizes in which the organisms lie densely 

 packed together without any definite arrangement. Out- 

 side them the organisms lie loose in the tissues, and 

 never arranged in chains. They have the form regarded 

 as typical of the tubercle bacillus, that is, they are 

 relatively long, slender, slightly curved rods, and for the 

 most part they present a richly-beaded appearance, due 

 to the vacuolation of their cell bodies. Round all these 



