92 TRANSACTIONS LIVERPOOL BIOLOGICAL SOCIETY. 



represents a part of the section shown in fig. 4, and it 

 should be referred to the extreme right of that figure. 

 It shows the fully developed sarcomatous cells. 



Here, then, as in the case of the tumour appearing 

 among the fat cells, we have a secondary process. A 

 previous process of fibrosis of connective and muscular 

 tissue has occurred, and then this fibrosed region has been 

 invaded, and finally is being replaced by a truly sarco- 

 matous, or malignant (an actively growing) tissue. 



Histology of the Tumours. 



The nodules are strictly non-vascular; absolutely no 

 traces of blood or lymph vessels can be made out in their 

 substance. They belong to no single type; thus figs. 2 

 to 5 of Plate III all represent parts of a single section of 

 one tumour. 



Fig. 5 represents the tissue near the margin of the 

 nodule. It is not part of the capsule; that consists of a 

 thin layer of fine fibres containing relatively few nuclei. 

 Near to the margin these fibres pass into a network of 

 loosely interlaced fibres, each of which is a connective 

 tissue cell, spindle-shaped, but with the extremities of the 

 cell greatly prolonged. Some of these cells possess two 

 nuclei. The latter are ellipsoidal in shape. Accom- 

 panying this network of connective tissue cells is a fine 

 stroma, but this is greatly reduced. 



This tissue passes into that represented in fig. 2, 

 which consists of a rather dense mass of typical spindle- 

 cells. These run in various directions. Among them 

 are, apparently, a few smaller, spherical cells, but such 

 are probably spindle-cells like the rest, but seen end-on. 

 The stroma is almost entirely absent. The growth here 

 is obviously a typical spindle-celled sarcoma. 



Parts of the same tumour are formed from cells such 

 as those represented in fig. 3. These are all small and 

 round. There are tv^'cal nuclei with very little cell- 



